Dunnill M S, Gatter K C
Histopathology. 1986 May;10(5):461-75. doi: 10.1111/j.1365-2559.1986.tb02498.x.
Sixty-six lung carcinomas have been examined by light and electron microscopy, as well as by immunocytochemical techniques using a panel of monoclonal antibodies. There was considerable heterogeneity with regard to cell type and in only 18 cases was it possible to classify the tumour as a solely small cell, squamous or adenocarcinoma. In the remaining cases there was evidence of two or three cell types. These findings support the thesis that all lung cancers are derived from a pluripotential basal or reserve cell in the bronchial mucosa which may proliferate along one or more lines of differentiation. This view of the histogenesis of lung cancer would account for the heterogeneous appearance of many tumours and the difficulty experienced in placing them in one of the standard classifications.
我们采用一组单克隆抗体，通过光镜、电镜以及免疫细胞化学技术对66例肺癌进行了检查。在细胞类型方面存在相当大的异质性，只有18例肿瘤能够被明确分类为单纯的小细胞癌、鳞癌或腺癌。在其余病例中，有证据表明存在两种或三种细胞类型。这些发现支持了这样一种观点，即所有肺癌均起源于支气管黏膜中的多能基底细胞或储备细胞，这些细胞可能沿着一条或多条分化途径增殖。这种肺癌组织发生的观点可以解释许多肿瘤的异质性外观以及将它们归入标准分类之一时所遇到的困难。
