Kontodimopoulos Nick, Stamatopoulou Eleni, Kletsas Georgios, Kandili Anna
Faculty of Social Sciences, Hellenic Open University , Patras, Greece.
Division of Management, "KAT" General Hospital , Athens, Greece.
Expert Rev Pharmacoecon Outcomes Res. 2020 Dec;20(6):595-602. doi: 10.1080/14737167.2020.1677156. Epub 2019 Oct 22.
: This study looks deeper into the relationship between rheumatoid arthritis (RA) disease activity and distinct dimensions of sleep quality. : The Pittsburgh Sleep Quality Index (PSQI) was administered to a cohort of 147 RA patients. Health-related quality of life (HRQoL) and fatigue were measured with the SF-12 and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) instruments, respectively, whereas RA activity was determined with the Disease Activity Score 28 joints (DAS28). Ethical approval for the study and informed consent from the participants were obtained. : Most patients were females (78.2%), and the mean age of the entire sample was 63.7 years. Most participants (77.6%) were poor sleepers (i.e. PSQI ≥ 5) who suffered from fatigue more than good sleepers (FACIT-F: 21.6 vs. 39.3, < 0.001). Overall sleep quality correlated, in the expected directions, with disease activity (Spearman's rho = 0.87, < 0.001), physical health (-0.66, < 0.001), mental health (-0.71, < 0.001), and fatigue (0.87, < 0.001). PSQI and its component scores differed across patient subgroups with increasing RA activity, even after adjusting for confounding variables. : RA disease activity distinctly affects sleep quality, and given the already demonstrated importance of good sleep, this 'deeper look' might contribute to the effort to improve HRQoL in RA patients.
本研究更深入地探讨了类风湿性关节炎（RA）疾病活动与睡眠质量不同维度之间的关系。对147名RA患者进行了匹兹堡睡眠质量指数（PSQI）评估。分别使用SF-12和慢性病治疗功能评估-疲劳量表（FACIT-F）测量健康相关生活质量（HRQoL）和疲劳程度，而RA活动则通过28个关节疾病活动评分（DAS28）来确定。该研究获得了伦理批准并取得了参与者的知情同意。大多数患者为女性（78.2%），整个样本的平均年龄为63.7岁。大多数参与者（77.6%）睡眠质量较差（即PSQI≥5），与睡眠良好者相比，他们更容易感到疲劳（FACIT-F：21.6对39.3，P<0.001）。总体睡眠质量与疾病活动（斯皮尔曼等级相关系数rho=0.87，P<0.001）、身体健康（-0.66，P<0.001）、心理健康（-0.71，P<0.001）和疲劳程度（0.87，P<0.001）在预期方向上相关。即使在调整混杂变量后，PSQI及其各成分得分在RA活动增加的患者亚组中也存在差异。RA疾病活动明显影响睡眠质量，鉴于良好睡眠已被证明的重要性，这种“更深入的研究”可能有助于努力改善RA患者的HRQoL。
