Cheng Jingyun, Xie Hui, Yang Hao, Wang Ke, Xu Guobin, Wu Guangyao
Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province 430071, China.
Department of Radiology, Zhongshan Hospital of Wuhan University, Wuhan, Hubei Province 430071, China.
Gastroenterol Res Pract. 2018 Jul 22;2018:7351936. doi: 10.1155/2018/7351936. eCollection 2018.
To explore the feasibility of computed tomography enterography (CTE) in the quantitative evaluation of the activity of Crohn's disease (CD).
There were 49 CD patients with whole clinical, enteroscopy, and CTE data to be analyzed retrospectively. The patients were graded as inactive (0-2), mild (3-6), and moderate-severe group (>6) based on simplified endoscopic activity score for Crohn's disease (SES-CD). The differences in bowel wall thickening, mural hyperenhancement in the portal vein period, and the ΔCT values were analyzed among groups using ANOVA (analysis of variance) and test. Then, the parameters were correlated with SES-CD, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR).
In the 49 patients, 13 ones were inactive, 19 ones were mild, and 17 ones were moderate-severe; the thickness of bowel wall, mural hyperenhancement in the portal vein period, and ΔCT value among groups were all significantly different ( < 0.001 in all). Correlative analysis showed that compared with the SES-CD, the bowel wall thickening ( = 0.564, < 0.001), mural hyperenhancement in the portal vein period ( = 0.585, < 0.001), and ΔCT value ( = 0.533, < 0.001) were moderately correlated.
The mural hyperenhancement in the portal vein period, bowel wall thickening, and ΔCT value can accurately and quantitatively assess the activity of CD lesions and are potential visual biomarkers of CD lesions.
探讨计算机断层扫描小肠造影（CTE）在克罗恩病（CD）活动度定量评估中的可行性。
回顾性分析49例有完整临床、肠镜及CTE数据的CD患者。根据克罗恩病简化内镜活动度评分（SES-CD）将患者分为非活动组（0 - 2分）、轻度组（3 - 6分）和中重度组（>6分）。采用方差分析（ANOVA）和检验分析各组肠壁增厚、门静脉期壁强化及ΔCT值的差异。然后，将这些参数与SES-CD、C反应蛋白（CRP）及红细胞沉降率（ESR）进行相关性分析。
49例患者中，13例为非活动期，19例为轻度，17例为中重度；各组间肠壁厚度、门静脉期壁强化及ΔCT值均有显著差异（均P<0.001）。相关性分析显示，与SES-CD相比，肠壁增厚（r = 0.564，P<0.001）、门静脉期壁强化（r = 0.585，P<0.001）及ΔCT值（r = 0.533，P<0.001）呈中度相关。
门静脉期壁强化、肠壁增厚及ΔCT值可准确、定量地评估CD病变的活动度，是CD病变潜在的可视化生物标志物。
