Cleary M L, Galili N, Sklar J
J Exp Med. 1986 Jul 1;164(1):315-20. doi: 10.1084/jem.164.1.315.
Our results indicate that there are two major breakpoint cluster regions in chromosome 18 DNA for t(14;18) translocations in follicular lymphomas. The absence of a pFL-1 homologous transcript in a cell line containing a pFL-2-detectable translocation suggests that there may be two different pathogenetic consequences of t(14;18) translocations. One possibility is that, despite the distances between them (greater than 20 kb), breakpoints in the two cluster regions in some way affect transcription of the same gene product, which has not yet been identified. Alternatively, two separate transcriptional units may be involved. The availability of DNA probes for each of the two t(14;18) breakpoint cluster regions will allow further studies regarding the biologic significance of these two genetically distinct classes of t(14;18) translocations.
我们的研究结果表明，在滤泡性淋巴瘤中，18号染色体DNA上存在两个主要的断裂点簇区域，用于t(14;18)易位。在一个含有可检测到pFL-2易位的细胞系中缺乏pFL-1同源转录本，这表明t(14;18)易位可能有两种不同的致病后果。一种可能性是，尽管两个簇区域之间的距离（大于20 kb），但某些情况下两个簇区域中的断裂点以某种方式影响同一基因产物的转录，而该基因产物尚未被鉴定。或者，可能涉及两个独立的转录单位。针对两个t(14;18)断裂点簇区域中的每一个的DNA探针的可用性，将允许对这两种遗传上不同类型的t(14;18)易位的生物学意义进行进一步研究。
