人类滤泡性淋巴瘤中第二个t(14;18)断点簇区域的检测
Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas.
作者信息
Cleary M L, Galili N, Sklar J
出版信息
J Exp Med. 1986 Jul 1;164(1):315-20. doi: 10.1084/jem.164.1.315.
Abstract
Our results indicate that there are two major breakpoint cluster regions in chromosome 18 DNA for t(14;18) translocations in follicular lymphomas. The absence of a pFL-1 homologous transcript in a cell line containing a pFL-2-detectable translocation suggests that there may be two different pathogenetic consequences of t(14;18) translocations. One possibility is that, despite the distances between them (greater than 20 kb), breakpoints in the two cluster regions in some way affect transcription of the same gene product, which has not yet been identified. Alternatively, two separate transcriptional units may be involved. The availability of DNA probes for each of the two t(14;18) breakpoint cluster regions will allow further studies regarding the biologic significance of these two genetically distinct classes of t(14;18) translocations.
摘要
我们的研究结果表明，在滤泡性淋巴瘤中，18号染色体DNA上存在两个主要的断裂点簇区域，用于t(14;18)易位。在一个含有可检测到pFL-2易位的细胞系中缺乏pFL-1同源转录本，这表明t(14;18)易位可能有两种不同的致病后果。一种可能性是，尽管两个簇区域之间的距离（大于20 kb），但某些情况下两个簇区域中的断裂点以某种方式影响同一基因产物的转录，而该基因产物尚未被鉴定。或者，可能涉及两个独立的转录单位。针对两个t(14;18)断裂点簇区域中的每一个的DNA探针的可用性，将允许对这两种遗传上不同类型的t(14;18)易位的生物学意义进行进一步研究。
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本文引用的文献
1
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N Engl J Med. 1982 Nov 11;307(20):1231-6. doi: 10.1056/NEJM198211113072002.
2
Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma.免疫球蛋白基因重排作为B细胞淋巴瘤的诊断标准。
Proc Natl Acad Sci U S A. 1984 Jan;81(2):593-7. doi: 10.1073/pnas.81.2.593.
3
Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis.利用寡脱氧核苷酸定向诱变构建改良的M13载体。
Gene. 1983 Dec;26(1):101-6. doi: 10.1016/0378-1119(83)90040-9.
4
Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes.人类免疫球蛋白μ基因座的结构：胚胎期及重排的J基因和D基因的特征分析
Cell. 1981 Dec;27(3 Pt 2):583-91. doi: 10.1016/0092-8674(81)90400-1.
5
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6
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.B细胞肿瘤中涉及的t(14;18)染色体易位是由VDJ连接错误导致的。
Science. 1985 Sep 27;229(4720):1390-3. doi: 10.1126/science.3929382.
7
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Cell. 1985 Jul;41(3):899-906. doi: 10.1016/s0092-8674(85)80070-2.
8
Correction of a nucleotide-excision-repair mutation by human chromosome 19 in hamster-human hybrid cells.人19号染色体对仓鼠-人杂交细胞中核苷酸切除修复突变的校正
Somat Cell Mol Genet. 1985 Jan;11(1):87-92. doi: 10.1007/BF01534738.
9
Histiocytic lymphoma cell lines: immunologic and cytogenetic studies.
Cancer Genet Cytogenet. 1985 Jan 15;14(3-4):205-18. doi: 10.1016/0165-4608(85)90186-4.
10
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Science. 1985 Jun 21;228(4706):1440-3. doi: 10.1126/science.3874430.
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