Louveau Antoine
Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Methods Mol Biol. 2018;1845:31-45. doi: 10.1007/978-1-4939-8709-2_3.
For decades, the brain has been considered an immune-privileged organ, meaning that the brain was mainly ignored by the immune system and that the presence of immune cells, notably of the adaptive arm, was a hallmark of pathological conditions. Over the past few decades, the definition of the immune privilege continues to be refined. There has been evidence accumulating that shows that the immune system plays a role in proper brain function. This evidence may represent an effective source of therapeutic targets for neurological disorders. In this chapter, we discuss the recent advances in understanding the immunity of the brain and describe how tertiary lymphoid structures can be generated in the central nervous system, which might represent a new avenue to treat neurological disorders.
几十年来，大脑一直被视为免疫特权器官，这意味着免疫系统主要忽略大脑，且免疫细胞（尤其是适应性免疫分支的细胞）的存在是病理状态的标志。在过去几十年里，免疫特权的定义不断完善。越来越多的证据表明，免疫系统在大脑的正常功能中发挥作用。这些证据可能是神经疾病治疗靶点的有效来源。在本章中，我们将讨论在理解大脑免疫方面的最新进展，并描述中枢神经系统中如何产生三级淋巴结构，这可能代表了治疗神经疾病的新途径。
