Kasuya Y, Utsunomiya N, Matsuki N
J Pharmacobiodyn. 1986 Mar;9(3):239-43. doi: 10.1248/bpb1978.9.239.
Chronic effects of highly purified eicosapentaenoic acid (EPA) on systolic blood pressure in spontaneously hypertensive rats (SHR) and normotensive rats were studied. Daily oral administration of 30 to 300 mg/kg EPA for eight weeks significantly decreased the development of hypertension in SHR dose-dependently. Eight weeks treatment of 30, 100, and 300 mg/kg EPA reduced mean systolic blood pressure by 23, 29, and 32 mmHg, respectively, compared to untreated rats. Hypotensive effect of EPA progressed slowly and was reversible after the termination of the treatment. However, daily administration of EPA to normotensive rats did not affect the systolic blood pressure. EPA may be useful as a hypotensive agent for treatment of hypertension.
研究了高纯度二十碳五烯酸（EPA）对自发性高血压大鼠（SHR）和正常血压大鼠收缩压的慢性影响。连续八周每日口服30至300mg/kg EPA可显著剂量依赖性地降低SHR的高血压发展。与未治疗的大鼠相比，30、100和300mg/kg EPA治疗八周分别使平均收缩压降低了23、29和32mmHg。EPA的降压作用进展缓慢，治疗终止后可逆。然而，对正常血压大鼠每日给予EPA并不影响收缩压。EPA可能作为一种降压剂用于治疗高血压。
