Laboratory Animal Center, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China.
Biomolecules. 2018 Aug 23;8(3):80. doi: 10.3390/biom8030080.
Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture, vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute cardiovascular disease. Atherosclerosis-related inflammation is mediated by proinflammatory cytokines, inflammatory signaling pathways, bioactive lipids, and adhesion molecules. This review discusses the effects of inflammation and the systemic inflammatory signaling pathway on atherosclerosis, the role of related signaling pathways in inflammation, the formation of atherosclerosis plaques, and the prospects of treating atherosclerosis by inhibiting inflammation.
动脉粥样硬化是一种慢性炎症性疾病；不稳定的动脉粥样硬化斑块破裂、血小板聚集和血栓形成导致血管狭窄或闭塞，进而引发急性心血管疾病。与动脉粥样硬化相关的炎症是由促炎细胞因子、炎症信号通路、生物活性脂质和黏附分子介导的。本文综述了炎症和系统性炎症信号通路对动脉粥样硬化的影响、相关信号通路在炎症、动脉粥样硬化斑块形成中的作用，以及通过抑制炎症治疗动脉粥样硬化的前景。
