The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010030, China.
The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010000, China.
Sci Rep. 2018 Aug 24;8(1):12782. doi: 10.1038/s41598-018-31146-6.
Lumbar disc herniation (LDH) is a low back pain disorder and associated with several single nucleotide polymorphisms (SNPs). However, the role of brain-derived neurotrophic factor (BDNF) and BDNFOS gene in LDH susceptibility remains unknown. To examine whether the variants contribute to LDH, 7 SNPs were genotyped in 380 patients and 692 healthy controls among Han Chinese population. Multiple genetic models, stratification by age/gender and haploview analysis was used by calculating odds ratio (OR) and 95% confidence intervals (CIs). Rs11030064 in BDNFOS gene was associated with modified susceptibility for LDH at age ≤50 years but three loci (rs6265, rs11030104 and rs10767664) of BDNF gene increased LDH risk at age >50 years. Further, rs11030096 polymorphism in BDNFOS gene was associated with LDH the increased susceptibility of LDH in females. Haplotype analysis shown that haplotype "GCC" in the block (rs988712, rs7481311, and rs11030064) increased LDH risk (OR = 1.49, 95% CI = 1.06-2.10, p = 0.022) at age ≤50 years. However, there was no significant association between BDNF/BDNFOS gene and LDH risk in the overall before stratified analysis. For the first time, our results provide evidence on polymorphism of BDNF / BDNFOS gene associated with LDH risk in Chinese Han population.
腰椎间盘突出症（LDH）是一种腰痛疾病，与几个单核苷酸多态性（SNPs）有关。然而，脑源性神经营养因子（BDNF）和 BDNFOS 基因在 LDH 易感性中的作用尚不清楚。为了研究这些变体是否导致 LDH，在汉族人群中，对 380 名患者和 692 名健康对照者的 7 个 SNP 进行了基因分型。通过计算比值比（OR）和 95％置信区间（CI），使用多种遗传模型、按年龄/性别分层和 haploview 分析来研究变体是否与 LDH 易感性相关。BDNFOS 基因中的 rs11030064 与 50 岁以下年龄的 LDH 易感性改变有关，但 BDNF 基因的三个位点（rs6265、rs11030104 和 rs10767664）增加了 50 岁以上年龄的 LDH 风险。此外，BDNFOS 基因中的 rs11030096 多态性与女性 LDH 的易感性增加有关。单体型分析表明，该块中的单体型“GCC”（rs988712、rs7481311 和 rs11030064）增加了 LDH 风险（OR=1.49，95％CI=1.06-2.10，p=0.022），年龄在 50 岁以下。然而，在分层分析之前，BDNF/BDNFOS 基因与 LDH 风险之间没有显著关联。这是首次研究结果表明 BDNF/BDNFOS 基因的多态性与中国汉族人群的 LDH 风险有关。
