College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
J Pharm Biomed Anal. 2018 Oct 25;160:276-288. doi: 10.1016/j.jpba.2018.08.009. Epub 2018 Aug 7.
Paeoniae Radix Alba (baishao or white peony root) and Paeoniae Radix Rubra (chishao or red peony root) are two highly valuable traditional Chinese medicines (TCMs) usually indicated for painful conditions, menstrual disorders and viral infections. These two TCMs are collectively referred to as shaoyao (Paeoniae Radix) due to their close origins and similar chemical compositions. Modern research indicates that monoterpene glycosides, polyphenols and paeonols are the three main types of compounds related to the pharmacological activities of Paeoniae Radix. This review summarizes recent advances in the chemical analysis of Paeoniae Radix and the related traditional Chinese medicine formulas/preparations, including methods used for sample pretreatment, qualitative analysis, quantitative analysis and biological sample analysis. More than 120 papers are discussed in this review, focusing on the chemical analysis of Paeoniae Radix, and various analytical techniques (such as HPLC, LC-MS, IR, near IR and quantitative NMR), as well as their advantages/disadvantages, are described. It is our hope that this paper can provide necessary information for improving the quality evaluation methods currently available for Paeoniae Radix and offer a scientific basis for the future in-depth study of the pharmacokinetics and pharmacodynamics of Paeoniae Radix.
白芍（baishao 或 white peony root）和赤芍（chishao 或 red peony root）是两种极具价值的中药，通常用于治疗疼痛、月经失调和病毒感染等病症。由于这两种中药来源相近、化学成分相似，常被归为芍药（Paeoniae Radix）一类。现代研究表明，单萜糖苷、多酚和丹皮酚是与白芍药理活性相关的三种主要化合物类型。本综述总结了白芍及其相关中药方剂/制剂的化学分析方面的最新进展，包括样品预处理、定性分析、定量分析和生物样品分析等方法。本综述讨论了 120 多篇论文，重点介绍了白芍的化学分析，以及各种分析技术（如 HPLC、LC-MS、IR、近红外和定量 NMR），并描述了它们的优缺点。希望本文能为改进白芍的质量评价方法提供必要的信息，为今后深入研究白芍的药代动力学和药效学提供科学依据。
