[中药白芍的现代研究进展及其Q-标志物预测]
[Modern research progress of traditional Chinese medicine Paeoniae Radix Alba and prediction of its Q-markers].
作者信息
Xu Jia-Xin, Xu Jun, Cao Yong, Zhu Yue-Jian, Li Xiang-Yu, Ge De-Zhu, Ma Lei, Zhang Tie-Jun, Liu Chang-Xiao
机构信息
School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine Tianjin 300193, China.
Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research Tianjin 300301, China State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research Tianjin 300301, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2021 Nov;46(21):5486-5495. doi: 10.19540/j.cnki.cjcmm.20210818.201.
Paeoniae Radix Alba is the dried root of Paeonia lactiflora, which was first recorded in the Shennong's Classic of Materia Medica and listed as the top grade. It is a common blood-tonifying herb, and its chemical components are mainly monoterpenes and their glycosides, triterpenes, flavonoids and so on. Modern research has demonstrated that Paeoniae Radix Alba has the activities of anti-inflammation, pain easing, liver protection, and anti-oxidation, and thus it is widely used in clinical practice and has broad development prospects. In this paper, the research progress on the chemical composition, pharmacological effects, and quality control of Paeoniae Radix Alba were summarized. On this basis, the Q-markers of Paeoniae Radix Alba were predicted from the aspects of mass transfer and traceability, chemical composition specificity, and availability and measurability of chemical components, which will provide a scientific basis for the quality evaluation of Paeoniae Radix Alba.
白芍为毛茛科植物芍药的干燥根，最早记载于《神农本草经》，列为上品。它是一种常用的补血药，其化学成分主要有单萜及其苷类、三萜类、黄酮类等。现代研究表明，白芍具有抗炎、止痛、保肝、抗氧化等活性，因而在临床中广泛应用，具有广阔的发展前景。本文综述了白芍的化学成分、药理作用及质量控制方面的研究进展。在此基础上，从物质传递与溯源性、化学成分特异性、化学成分的可获得性与可测性等方面对白芍的Q-标志物进行了预测，为白芍的质量评价提供科学依据。
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