Zhang Yi, Yang Yuling, Ruan Jingya, Chen Qiu, Li Jian, Guo Yuanqiang, Han Lifeng, Wang Tao
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China; Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshan Road, Nankai District, Tianjin 300193, China.
Tianjin Key Laboratory of Molecular Drug Research, College of Chemistry, Nankai University, Tianjin 300071, China.
Fitoterapia. 2018 Jan;124:66-72. doi: 10.1016/j.fitote.2017.10.019. Epub 2017 Oct 23.
A phytochemical investigation to obtain new triglyceride (TG) accumulation inhibitors resulted in the isolation of six new isobenzofuranones, leontopodiols A (1), B (2), leontopodiosides C (3), D (4), E (5), F (6), together with three known ones (7-9) from the aerial parts of Leontopodium leontopodioides (Willd.) Beauv. The structures of these isolates were identified by routine NMR experiments, optical rotation determination, electronic circular dichroism (ECD) calculation, along with chemical reaction. Moreover, compounds 1, 2, 5, and 7-9 displayed TG accumulation inhibitory effects on HepG2 cells.
为了获得新的甘油三酯（TG）积累抑制剂而进行的植物化学研究，从火绒草（Leontopodium leontopodioides (Willd.) Beauv.）的地上部分分离出了6个新的异苯并呋喃酮类化合物，即火绒草二醇A（1）、B（2）、火绒草苷C（3）、D（4）、E（5）、F（6），以及3个已知化合物（7 - 9）。通过常规核磁共振实验、旋光度测定、电子圆二色光谱（ECD）计算以及化学反应确定了这些分离物的结构。此外，化合物1、2、5和7 - 9对HepG2细胞显示出TG积累抑制作用。
