Lim Seung-Taek, Park Jin-Kee, Park Sang-Hyuk, Lee Eun-Jae, Kim Woo-Nam, Min Seok-Ki
J Exerc Nutrition Biochem. 2018 Jun 30;22(2):18-22. doi: 10.20463/jenb.2018.0012.
Elastin is one of the major determinants of arterial distensibility of large blood vessels that forms the principal component of elastic fibers from the media of arteries. However, the association between elastin(ELN) genotype and vascular function is still unclear.
120women were recruited from the Saha-gu (Busan, Korea) Community Center. Measurements of body composition and vascular function included carotid intima-media thickness (CIMT), carotid artery luminal diameter (CLD), minimum (diastolic) artery luminal diameter (CLDmin) and maximum (systolic) artery luminal diameter (CLDmax). Genotyping for the ELN (rs 2071307) polymorphism was performed using the TaqMan approach. ELN gene distribution of subjects were in the Hardy-Weinberg equilibrium (p=0.402).
The relative CIMT differed significantly among the ELN genotypes. And not significant differences in CLD and CIMT/CLD ratio, but AA genotype was tended higher than other genotypes (AG and GG). The relative CIMT and CLD min differed significantly between the ELN alleles. And not significant differences in CLD max and CIMT/CLD ratio, but A allele was tended higher than G allele.
These results suggest that ELN gene polymorphism might be used a one of the genetic determinants of vascular disease in both pre- and postmenopausal women.
弹性蛋白是大动脉动脉扩张性的主要决定因素之一，它构成动脉中膜弹性纤维的主要成分。然而，弹性蛋白（ELN）基因型与血管功能之间的关联仍不清楚。
从韩国釜山沙下区社区中心招募了120名女性。身体成分和血管功能的测量包括颈动脉内膜中层厚度（CIMT）、颈动脉管腔直径（CLD）、最小（舒张期）动脉管腔直径（CLDmin）和最大（收缩期）动脉管腔直径（CLDmax）。使用TaqMan方法对ELN（rs 2071307）多态性进行基因分型。受试者的ELN基因分布处于哈迪-温伯格平衡（p = 0.402）。
ELN基因型之间的相对CIMT存在显著差异。CLD和CIMT/CLD比值无显著差异，但AA基因型往往高于其他基因型（AG和GG）。ELN等位基因之间的相对CIMT和CLDmin存在显著差异。CLDmax和CIMT/CLD比值无显著差异，但A等位基因往往高于G等位基因。
这些结果表明，ELN基因多态性可能是绝经前和绝经后女性血管疾病的遗传决定因素之一。
