氟烷对单纯疱疹病毒1型复制的抑制作用。
Inhibition of herpes simplex virus type 1 replication by halothane.
作者信息
Bedows E, Holland T C, Knight P R
出版信息
Antimicrob Agents Chemother. 1986 May;29(5):941-4. doi: 10.1128/AAC.29.5.941.
Abstract
Halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) inhibited herpes simplex virus type 1 (HSV-1) replication, although HSV-1 DNA was synthesized at normal levels in Vero cells. Viral capsids and extracellular virions were inhibited, and HSV-1 protein synthesis decreased by 50%, although no specific HSV-1 protein failed to be synthesized. Hyperbaric pressure failed to reverse the halothane-induced inhibition of HSV-1 replication.
摘要
氟烷（2-溴-2-氯-1,1,1-三氟乙烷）可抑制1型单纯疱疹病毒（HSV-1）的复制，尽管在非洲绿猴肾细胞（Vero细胞）中HSV-1 DNA能以正常水平合成。病毒衣壳和细胞外病毒粒子受到抑制，HSV-1蛋白合成减少了50%，不过并没有特定的HSV-1蛋白未能合成。高压未能逆转氟烷对HSV-1复制的诱导抑制作用。
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