Gibson W, Roizman B
J Virol. 1972 Nov;10(5):1044-52. doi: 10.1128/JVI.10.5.1044-1052.1972.
Two classes of herpesvirus capsids, designated A and B, were isolated from the nuclei of human cells infected with herpes simplex virus (HSV). A and B capsids share in common four structural proteins, i.e., no. 5, 19, 23, and 24. B capsids contain 7.7 to 9.7 times more deoxyribonucleic acid than A capsids; moreover, they contain proteins no. 21 and 22a in addition. All of the proteins contained in the capsid except no. 22a are present in the enveloped nucleocapsids (virions) in approximately the same molar ratios. The capsid proteins of HSV-1 cannot be differentiated from their HSV-2 counterparts with respect to electrophoretic mobility. A third class of capsids, designated C capsids, was isolated from virions contained in the cytoplasm of infected cells by the same procedure used to obtain A and B capsids. The C capsids contain all of the proteins present in A capsids plus proteins 1 to 3 and 21.
从感染单纯疱疹病毒（HSV）的人类细胞核中分离出两类疱疹病毒衣壳，分别命名为A类和B类。A类和B类衣壳共有四种结构蛋白，即5号、19号、23号和24号蛋白。B类衣壳所含的脱氧核糖核酸比A类衣壳多7.7至9.7倍；此外，B类衣壳还含有21号和22a号蛋白。衣壳中除22a号蛋白外的所有蛋白，在包膜核衣壳（病毒体）中的摩尔比大致相同。就电泳迁移率而言，HSV-1的衣壳蛋白与其HSV-2对应蛋白无法区分。通过用于获取A类和B类衣壳的相同程序，从感染细胞细胞质中的病毒体中分离出第三类衣壳，即C类衣壳。C类衣壳包含A类衣壳中存在的所有蛋白，以及1至3号蛋白和21号蛋白。
