辅助克拉维酸消除实验性耐甲氧西林金黄色葡萄球菌心内膜炎大鼠模型中的头孢唑林接种效应。
Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis.
机构信息
Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, McGovern Medical School, Houston, Texas, USA
Department of Internal Medicine, Division of Infectious Diseases, UTHealth, McGovern Medical School, Houston, Texas, USA.
出版信息
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01158-18. Print 2018 Nov.
Abstract
We tested the ability of clavulanic acid to restore the efficacy of cefazolin against TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts (7.1 ± 0.5 log CFU/g) compared to that with cefazolin alone (2 ± 0.6 log CFU/g; < 0.0001). The addition of a β-lactamase inhibitor may be a viable strategy for overcoming the CzIE.
摘要
我们测试了克拉维酸恢复头孢唑林对 TX0117 疗效的能力，TX0117 表现出头孢唑林接种效应（CzIE）。在大鼠感染性心内膜炎模型中，与单独使用头孢唑林（2 ± 0.6 log CFU/g；< 0.0001）相比，头孢唑林加克拉维酸联合给药可显著降低细菌计数（7.1 ± 0.5 log CFU/g）。添加β-内酰胺酶抑制剂可能是克服 CzIE 的可行策略。
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