• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis.辅助克拉维酸消除实验性耐甲氧西林金黄色葡萄球菌心内膜炎大鼠模型中的头孢唑林接种效应。
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01158-18. Print 2018 Nov.
2
Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis.头孢洛林对在大鼠心内膜炎模型中表现出头孢唑林高接种量效应的甲氧西林敏感金黄色葡萄球菌的疗效。
Antimicrob Agents Chemother. 2017 Jun 27;61(7). doi: 10.1128/AAC.00324-17. Print 2017 Jul.
3
Relapse of type A beta-lactamase-producing Staphylococcus aureus native valve endocarditis during cefazolin therapy: revisiting the issue.头孢唑林治疗期间产A组β-内酰胺酶金黄色葡萄球菌自体瓣膜心内膜炎复发：重新审视该问题。
Clin Infect Dis. 2003 Nov 1;37(9):1194-8. doi: 10.1086/379021. Epub 2003 Oct 1.
4
Prevalence of a cefazolin inoculum effect associated with blaZ gene types, and clinical outcomes among methicillin-susceptible Staphylococcus aureus blood isolates of patients with infective endocarditis.感染性心内膜炎患者耐甲氧西林金黄色葡萄球菌血培养分离株中与 blaZ 基因类型相关的头孢唑林接种效应的流行率和临床结局。
Infect Dis Now. 2023 Feb;53(1):104626. doi: 10.1016/j.idnow.2022.09.021. Epub 2022 Sep 30.
5
Novel Insights into the Classification of Staphylococcal β-Lactamases in Relation to the Cefazolin Inoculum Effect.新型头孢唑林接种效应相关葡萄球菌β-内酰胺酶分类的新见解。
Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.02511-19.
6
Clinical implications of cefazolin inoculum effect and β-lactamase type on methicillin-susceptible Staphylococcus aureus bacteremia.头孢唑林接种物效应及β-内酰胺酶类型对甲氧西林敏感金黄色葡萄球菌菌血症的临床影响
Microb Drug Resist. 2014 Dec;20(6):568-74. doi: 10.1089/mdr.2013.0229.
7
Prevalence of blaZ gene types and the cefazolin inoculum effect among methicillin-susceptible Staphylococcus aureus blood isolates and their association with multilocus sequence types and clinical outcome.甲氧西林敏感金黄色葡萄球菌血培养分离株中blaZ基因类型的流行情况、头孢唑林接种效应及其与多位点序列类型和临床结局的关联
Eur J Clin Microbiol Infect Dis. 2015 Feb;34(2):349-55. doi: 10.1007/s10096-014-2241-5. Epub 2014 Sep 12.
8
A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.头孢唑林接种物效应快速检测试验在耐甲氧西林金黄色葡萄球菌中的应用。
J Clin Microbiol. 2021 Mar 19;59(4). doi: 10.1128/JCM.01938-20.
9
Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children.头孢唑林接种效应与儿童甲氧西林敏感金黄色葡萄球菌骨关节炎感染
Antimicrob Agents Chemother. 2020 Aug 20;64(9). doi: 10.1128/AAC.00703-20.
10
Inoculum effect with cefazolin among clinical isolates of methicillin-susceptible Staphylococcus aureus: frequency and possible cause of cefazolin treatment failure.甲氧西林敏感金黄色葡萄球菌临床分离株中头孢唑林的接种物效应：头孢唑林治疗失败的频率及可能原因
Antimicrob Agents Chemother. 2009 Aug;53(8):3437-41. doi: 10.1128/AAC.00317-09. Epub 2009 Jun 1.

引用本文的文献

1
The Application of Rat Models in Infections.大鼠模型在感染中的应用。
Pathogens. 2024 May 21;13(6):434. doi: 10.3390/pathogens13060434.
2
Pharmacodynamics of Doripenem Alone and in Combination with Relebactam in an In Vitro Hollow-Fiber Dynamic Model: Emergence of Resistance of Carbapenemase-Producing and the Inoculum Effect.多尼培南单独及与瑞来巴坦联合在体外中空纤维动态模型中的药效学：产碳青霉烯酶菌株的耐药性出现及接种量效应
Antibiotics (Basel). 2023 Dec 7;12(12):1705. doi: 10.3390/antibiotics12121705.
3
Meropenem MICs at Standard and High Inocula and Mutant Prevention Concentration Inter-Relations: Comparative Study with Non-Carbapenemase-Producing and OXA-48-, KPC- and NDM-Producing .美罗培南在标准接种量和高接种量时的最低抑菌浓度及突变预防浓度的相互关系：与非产碳青霉烯酶菌株、产OXA-48、KPC和NDM菌株的比较研究
Antibiotics (Basel). 2023 May 8;12(5):872. doi: 10.3390/antibiotics12050872.
4
β-Lactams against the Fortress of the Gram-Positive Bacterium.β-内酰胺类药物对抗革兰阳性菌的堡垒。
Chem Rev. 2021 Mar 24;121(6):3412-3463. doi: 10.1021/acs.chemrev.0c01010. Epub 2020 Dec 29.
5
Cefazolin Inoculum Effect and Methicillin-Susceptible Staphylococcus aureus Osteoarticular Infections in Children.头孢唑林接种效应与儿童甲氧西林敏感金黄色葡萄球菌骨关节炎感染
Antimicrob Agents Chemother. 2020 Aug 20;64(9). doi: 10.1128/AAC.00703-20.
6
Tedizolid as Step-Down Therapy following Daptomycin versus Continuation of Daptomycin against Enterococci and Methicillin- and Vancomycin-Resistant Staphylococcus aureus in a Rat Endocarditis Model.替加环素作为达托霉素降阶梯治疗与达托霉素持续治疗对大鼠心内膜炎模型中肠球菌和耐甲氧西林及万古霉素金黄色葡萄球菌的比较。
Antimicrob Agents Chemother. 2020 Apr 21;64(5). doi: 10.1128/AAC.02303-19.
7
Inoculum effect of β-lactam antibiotics.β-内酰胺类抗生素的接种效应。
J Antimicrob Chemother. 2019 Oct 1;74(10):2825-2843. doi: 10.1093/jac/dkz226.

本文引用的文献

1
The Cefazolin Inoculum Effect Is Associated With Increased Mortality in Methicillin-Susceptible Bacteremia.头孢唑林接种物效应与甲氧西林敏感菌血症死亡率增加有关。
Open Forum Infect Dis. 2018 May 23;5(6):ofy123. doi: 10.1093/ofid/ofy123. eCollection 2018 Jun 1.
2
Prevalence of a Cefazolin Inoculum Effect Associated with Gene Types among Methicillin-Susceptible Staphylococcus aureus Isolates from Four Major Medical Centers in Chicago.芝加哥四大医疗中心耐甲氧西林金黄色葡萄球菌分离株中与头孢唑林种属效应相关的基因类型的流行率。
Antimicrob Agents Chemother. 2018 Jul 27;62(8). doi: 10.1128/AAC.00382-18. Print 2018 Aug.
3
Comparative outcomes of cefazolin versus nafcillin for methicillin-susceptible Staphylococcus aureus bacteraemia: a prospective multicentre cohort study in Korea.头孢唑林与萘夫西林治疗甲氧西林敏感金黄色葡萄球菌菌血症的比较结果：韩国一项前瞻性多中心队列研究。
Clin Microbiol Infect. 2018 Feb;24(2):152-158. doi: 10.1016/j.cmi.2017.07.001. Epub 2017 Jul 8.
4
Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis.头孢洛林对在大鼠心内膜炎模型中表现出头孢唑林高接种量效应的甲氧西林敏感金黄色葡萄球菌的疗效。
Antimicrob Agents Chemother. 2017 Jun 27;61(7). doi: 10.1128/AAC.00324-17. Print 2017 Jul.
5
Comparative Effectiveness of Cefazolin Versus Nafcillin or Oxacillin for Treatment of Methicillin-Susceptible Staphylococcus aureus Infections Complicated by Bacteremia: A Nationwide Cohort Study.头孢唑林与萘夫西林或苯唑西林治疗合并菌血症的耐甲氧西林金黄色葡萄球菌感染的疗效比较：一项全国性队列研究。
Clin Infect Dis. 2017 Jul 1;65(1):100-106. doi: 10.1093/cid/cix287.
6
Cefazolin versus Nafcillin for Methicillin-Sensitive Staphylococcus aureus Bloodstream Infection in a California Tertiary Medical Center.在加利福尼亚一家三级医疗中心，头孢唑林与萘夫西林治疗甲氧西林敏感金黄色葡萄球菌血流感染的比较
Antimicrob Agents Chemother. 2016 Jul 22;60(8):4684-9. doi: 10.1128/AAC.00243-16. Print 2016 Aug.
7
Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.金黄色葡萄球菌感染：流行病学、病理生理学、临床表现及管理
Clin Microbiol Rev. 2015 Jul;28(3):603-61. doi: 10.1128/CMR.00134-14.
8
Antistaphylococcal penicillins versus cephalosporins for definitive treatment of meticillin-susceptible Staphylococcus aureus bacteraemia: a systematic review and meta-analysis.抗葡萄球菌青霉素与头孢菌素治疗耐甲氧西林金黄色葡萄球菌菌血症的比较：系统评价和荟萃分析。
Int J Antimicrob Agents. 2014 Dec;44(6):486-92. doi: 10.1016/j.ijantimicag.2014.09.002. Epub 2014 Sep 19.
9
Clinical implications of cefazolin inoculum effect and β-lactamase type on methicillin-susceptible Staphylococcus aureus bacteremia.头孢唑林接种物效应及β-内酰胺酶类型对甲氧西林敏感金黄色葡萄球菌菌血症的临床影响
Microb Drug Resist. 2014 Dec;20(6):568-74. doi: 10.1089/mdr.2013.0229.
10
National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011.2011 年美国侵袭性耐甲氧西林金黄色葡萄球菌感染的国家负担。
JAMA Intern Med. 2013 Nov 25;173(21):1970-8. doi: 10.1001/jamainternmed.2013.10423.

辅助克拉维酸消除实验性耐甲氧西林金黄色葡萄球菌心内膜炎大鼠模型中的头孢唑林接种效应。

Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis.

机构信息

Center for Antimicrobial Resistance and Microbial Genomics, UTHealth, McGovern Medical School, Houston, Texas, USA

Department of Internal Medicine, Division of Infectious Diseases, UTHealth, McGovern Medical School, Houston, Texas, USA.

出版信息

Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01158-18. Print 2018 Nov.

DOI:10.1128/AAC.01158-18
PMID:30150459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6201062/
Abstract

We tested the ability of clavulanic acid to restore the efficacy of cefazolin against TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts (7.1 ± 0.5 log CFU/g) compared to that with cefazolin alone (2 ± 0.6 log CFU/g; < 0.0001). The addition of a β-lactamase inhibitor may be a viable strategy for overcoming the CzIE.

摘要

我们测试了克拉维酸恢复头孢唑林对 TX0117 疗效的能力，TX0117 表现出头孢唑林接种效应（CzIE）。在大鼠感染性心内膜炎模型中，与单独使用头孢唑林（2 ± 0.6 log CFU/g；< 0.0001）相比，头孢唑林加克拉维酸联合给药可显著降低细菌计数（7.1 ± 0.5 log CFU/g）。添加β-内酰胺酶抑制剂可能是克服 CzIE 的可行策略。