心脏手术患者的抗菌预防：术中头孢唑啉浓度与胸骨伤口感染。
Antimicrobial Prophylaxis for Patients Undergoing Cardiac Surgery: Intraoperative Cefazolin Concentrations and Sternal Wound Infections.
机构信息
College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Department of Pharmacy, St. Boniface Hospital, Winnipeg, Manitoba, Canada.
出版信息
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01360-18. Print 2018 Nov.
Abstract
This study characterizes the pharmacodynamics of antimicrobial prophylaxis and sternal wound infections following cardiac surgery. Duration of surgery and cefazolin plasma concentration during wound closure were independently associated with surgical site infection at 30 days. Furthermore, a duration of surgery of >346 min and a total cefazolin closure concentration of <104 mg/liter were significant thresholds for an increased risk of infection. This study provides new data that informs dosing strategies for effective antimicrobial prophylaxis (AP) in patients undergoing cardiac surgery with cardiopulmonary bypass.
摘要
本研究描述了心脏手术后抗菌预防和胸骨伤口感染的药效学。手术持续时间和缝合时头孢唑林的血浆浓度与术后 30 天的手术部位感染独立相关。此外，手术持续时间>346 分钟和头孢唑林总闭合浓度<104mg/L 是感染风险增加的显著阈值。本研究提供了新的数据，为体外循环心脏手术患者的有效抗菌预防（AP）提供了剂量策略信息。
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本文引用的文献
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Evaluation of cefazolin antimicrobial prophylaxis during cardiac surgery with cardiopulmonary bypass.心脏手术体外循环期间头孢唑啉抗菌预防的评价。
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Dosing antibiotic prophylaxis during cardiopulmonary bypass-a higher level of complexity? A structured review.体外循环期间使用抗生素预防剂量是否更复杂？一项系统评价。
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