Scalzitti David A, Harwood Kenneth J, Maring Joyce R, Leach Susan J, Ruckert Elizabeth A, Costello Ellen
Int J MS Care. 2018 Jul-Aug;20(4):158-163. doi: 10.7224/1537-2073.2017-046.
Persons with multiple sclerosis (MS) commonly have difficulty walking. The 6-Minute Walk Test (6MWT) assesses functional capacity but may be considered burdensome for persons with MS, especially those with higher disability levels. The 2-Minute Walk Test (2MWT) may be an alternative measure to the 6MWT. The purpose of this study was to investigate the validity of the 2MWT in persons with MS.
Twenty-eight ambulatory persons with MS aged 18 to 64 years participated in this cross-sectional study. Participants completed five measures of walking performance (2MWT, 6MWT, usual and fast gait speed, and Timed Up and Go test) and two functional measures (Berg Balance Scale and five-times sit-to-stand test) during a testing session. Participants were classified into two subgroups based on Disease Steps scale classification.
The 2MWT was significantly correlated with the 6MWT (r = 0.947), usual gait speed (r = 0.920), fast gait speed (r = 0.942), the Timed Up and Go test (r = -0.911), and other functional measures. The 2MWT explained 89% of the variance seen during the 6MWT. The distances completed on the 2MWT and 6MWT accurately distinguished the subgroups.
This study demonstrated good construct and discriminant validity of the 2MWT in persons with MS, providing an efficient and practical alternative to the 6MWT. Validation of the 2MWT with other functional measures further supports these findings.
多发性硬化症（MS）患者通常行走困难。6分钟步行试验（6MWT）可评估功能能力，但对于MS患者，尤其是残疾程度较高的患者而言，可能会被认为负担较重。2分钟步行试验（2MWT）可能是6MWT的替代测量方法。本研究的目的是调查2MWT在MS患者中的有效性。
28名年龄在18至64岁之间的能行走的MS患者参与了这项横断面研究。参与者在一次测试中完成了五项步行性能测量（2MWT、6MWT、平常和快速步态速度以及计时起立行走测试）和两项功能测量（伯格平衡量表和五次坐立试验）。根据疾病阶段量表分类，将参与者分为两个亚组。
2MWT与6MWT（r = 0.947）、平常步态速度（r = 0.920）、快速步态速度（r = 0.942）、计时起立行走测试（r = -0.911）以及其他功能测量显著相关。2MWT解释了6MWT期间所见方差的89%。2MWT和6MWT上完成的距离准确区分了亚组。
本研究证明了2MWT在MS患者中具有良好的结构效度和区分效度，为6MWT提供了一种高效且实用的替代方法。2MWT与其他功能测量的效度验证进一步支持了这些发现。
