Puttick L, Ince P, Comaish J S
Br J Dermatol. 1986 Jul;115(1):111-6. doi: 10.1111/j.1365-2133.1986.tb06228.x.
We report three cases of eccrine poroma, present for many years, in which features were seen suggesting transformation from a benign to a malignant tumour. These changes ranged from in situ Bowenoid dysplasia to frankly invasive squamous carcinoma. The most helpful diagnostic feature in distinguishing the origin of the tumours was the presence of strong cytoplasmic staining for carcinoembryonic antigen (CEA) in cells surrounding, and giving rise to, neoplastic ducts and clefts. Dermatopathologists examining eccrine poromata should examine the lesions carefully for any evidence of malignant change.
我们报告了3例存在多年的小汗腺汗孔瘤病例，其中可见从良性肿瘤向恶性肿瘤转变的特征。这些变化范围从原位鲍温样发育异常到明显的浸润性鳞状细胞癌。区分肿瘤起源最有用的诊断特征是在肿瘤性导管和裂隙周围及产生这些结构的细胞中存在癌胚抗原（CEA）的强细胞质染色。检查小汗腺汗孔瘤的皮肤病理学家应仔细检查病变，寻找任何恶性变化的证据。
