Department of Chemical and Biomedical Engineering and School of Biomedical Science and Engineering, University of Maine, 5737 Jenness Hall, Orono, ME, 04469, USA.
John A. Paulson School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA, 021383, USA.
Adv Mater. 2018 Dec;30(50):e1802724. doi: 10.1002/adma.201802724. Epub 2018 Aug 27.
The development of new technologies is key to the continued improvement of medicine, relying on comprehensive materials design strategies that can integrate advanced therapeutic and diagnostic functions with a variety of surface properties such as selective adhesion, dynamic responsiveness, and optical/mechanical tunability. Liquid-infused surfaces have recently come to the forefront as a unique approach to surface coatings that can resist adhesion of a wide range of contaminants on medical devices. Furthermore, these surfaces are proving highly versatile in enabling the integration of established medical surface treatments alongside the antifouling capabilities, such as drug release or biomolecule organization. Here, the range of research being conducted on liquid-infused surfaces for medical applications is presented, from an understanding of the basics behind the interactions of physiological fluids, microbes, and mammalian cells with liquid layers to current applications of these materials in point-of-care diagnostics, medical tubing, instruments, implants, and tissue engineering. Throughout this exploration, the design parameters of liquid-infused surfaces and how they can be adapted and tuned to particular applications are discussed, while identifying how the range of controllable factors offered by liquid-infused surfaces can be used to enable completely new and dynamic approaches to materials and devices for human health.
新技术的发展是医学不断进步的关键，需要依靠综合的材料设计策略，将先进的治疗和诊断功能与多种表面特性（如选择性附着、动态响应和光学/机械可调性）集成在一起。液体注入表面最近成为一种独特的表面涂层方法，能够抵抗医疗器械上各种污染物的附着。此外，这些表面在实现与抗污染能力（如药物释放或生物分子组织）相结合的同时，还能够灵活地整合已有的医学表面处理方法。本文介绍了用于医学应用的液体注入表面的研究范围，从理解生理流体、微生物和哺乳动物细胞与液体层相互作用的基本原理，到这些材料在即时诊断、医疗管、器械、植入物和组织工程中的当前应用。在整个探索过程中，讨论了液体注入表面的设计参数以及如何根据特定应用进行调整和优化，并确定了液体注入表面提供的一系列可控因素如何用于为人类健康的材料和设备带来全新的动态方法。
