Farzaneh Maryam, Rahimi Fatemeh, Alishahi Masoumeh, Khoshnam Seyed E
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, Iran.
Curr Stem Cell Res Ther. 2019;14(1):9-13. doi: 10.2174/1574888X13666180821160421.
Cardiovascular Disease (CVD) is one of the world-wide healthcare problem that involves the heart or blood vessels. CVD includes myocardial infarction and coronary artery diseases (CAD). Dysfunctional myocardial cells are leading causes of low cardiac output or ventricular dysfunction after cardiac arrest and may contribute to the progression of CVD which could not generate new cardiomyocytes in human adult heart. The mesenchymal stem cells (MSCs) which are present in adult marrow can self-renew and have the capacity of differentiation into multiple types of cells including cardiomyocytes. Recent biochemical analyses greatly revealed that several regulators of MSCs, such as HGF, PDGF, Wnt, and Notch-1 signaling pathways have been shown to be involved in the proliferation and differentiation into cardiomyocytes. Preclinical studies are paving the way for further applications of MSCs in the repair of myocardial infarction. In this study, we discuss and summarize the paracrine mechanisms involved in MSCs differentiation into cardiomyocytes.
心血管疾病（CVD）是一个涉及心脏或血管的全球性医疗保健问题。CVD包括心肌梗死和冠状动脉疾病（CAD）。功能失调的心肌细胞是心脏骤停后心输出量降低或心室功能障碍的主要原因，并且可能导致CVD的进展，因为在人类成年心脏中无法产生新的心肌细胞。存在于成人骨髓中的间充质干细胞（MSCs）可以自我更新，并具有分化为多种类型细胞（包括心肌细胞）的能力。最近的生化分析极大地揭示了几种MSCs的调节因子，如HGF、PDGF、Wnt和Notch-1信号通路，已被证明参与了向心肌细胞的增殖和分化。临床前研究为MSCs在心肌梗死修复中的进一步应用铺平了道路。在本研究中，我们讨论并总结了MSCs分化为心肌细胞所涉及的旁分泌机制。
