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真菌数据库的新进展:一个基于网络的生物信息学平台,用于真菌和卵菌物种的组学规模数据分析。

What is new in FungiDB: a web-based bioinformatics platform for omics-scale data analysis for fungal and oomycete species.

机构信息

Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK.

Genomics England Limited, London E14 5AB, UK.

出版信息

Genetics. 2024 May 7;227(1). doi: 10.1093/genetics/iyae035.

Abstract

FungiDB (https://fungidb.org) serves as a valuable online resource that seamlessly integrates genomic and related large-scale data for a wide range of fungal and oomycete species. As an integral part of the VEuPathDB Bioinformatics Resource Center (https://veupathdb.org), FungiDB continually integrates both published and unpublished data addressing various aspects of fungal biology. Established in early 2011, the database has evolved to support 674 datasets. The datasets include over 300 genomes spanning various taxa (e.g. Ascomycota, Basidiomycota, Blastocladiomycota, Chytridiomycota, Mucoromycota, as well as Albuginales, Peronosporales, Pythiales, and Saprolegniales). In addition to genomic assemblies and annotation, over 300 extra datasets encompassing diverse information, such as expression and variation data, are also available. The resource also provides an intuitive web-based interface, facilitating comprehensive approaches to data mining and visualization. Users can test their hypotheses and navigate through omics-scale datasets using a built-in search strategy system. Moreover, FungiDB offers capabilities for private data analysis via the integrated VEuPathDB Galaxy platform. FungiDB also permits genome improvements by capturing expert knowledge through the User Comments system and the Apollo genome annotation editor for structural and functional gene curation. FungiDB facilitates data exploration and analysis and contributes to advancing research efforts by capturing expert knowledge for fungal and oomycete species.

摘要

FungiDB(https://fungidb.org)是一个宝贵的在线资源,它无缝集成了基因组和相关的大规模数据,涵盖了广泛的真菌和卵菌物种。作为 VEuPathDB 生物信息学资源中心(https://veupathdb.org)的一个组成部分,FungiDB 不断整合已发表和未发表的数据,以解决真菌生物学的各个方面的问题。该数据库成立于 2011 年初,现已发展到支持 674 个数据集。这些数据集包括 300 多个跨越不同分类群的基因组(例如子囊菌门、担子菌门、原生动物门、接合菌门、毛霉门以及网柄菌目、霜霉目、卵菌目和水霉目)。除了基因组组装和注释,还有 300 多个额外的数据集包含各种信息,如表达和变异数据。该资源还提供了一个直观的基于网络的界面,方便全面的数据挖掘和可视化。用户可以使用内置的搜索策略系统测试他们的假设,并浏览组学规模的数据集。此外,FungiDB 通过集成的 VEuPathDB Galaxy 平台提供了私人数据分析的功能。FungiDB 还通过用户评论系统和 Apollo 基因组注释编辑器捕获专家知识,实现了对基因组的改进,用于结构和功能基因的管理。FungiDB 促进了真菌和卵菌物种的数据探索和分析,并通过捕获专家知识为这些物种的研究工作做出了贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cc2/11075537/1f5c068ddb6e/iyae035f1.jpg

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