Scher R L, Feldman P S, Levine P A
Department of Otolaryngology-Head and Neck Surgery, University of Virginia, Charlottesville 22908.
Arch Otolaryngol Head Neck Surg. 1988 Mar;114(3):319-21. doi: 10.1001/archotol.1988.01860150101023.
An 82-year-old woman had a small-cell carcinoma of the parotid gland with cells containing neuroendocrine secretory granules. To our knowledge, these dense-core granules have been identified in only three other major salivary gland small-cell carcinomas. The findings of histologic and ultrastructural evaluations of this neoplasm suggested a salivary duct cell origin. The tumor appears to arise from cells of the salivary duct system that differentiate into cells with either neuroendocrine or epithelial features. Electron microscopy to determine the type of small-cell carcinoma should be performed, as this may have prognostic significance. Aggressive therapy should be undertaken, since small-cell carcinomas of the major salivary glands appear to have a better prognosis than bronchogenic or laryngeal small-cell carcinomas have.
一名82岁女性患有腮腺小细胞癌，其细胞含有神经内分泌分泌颗粒。据我们所知，这种致密核心颗粒仅在另外三例主要唾液腺小细胞癌中被发现。该肿瘤组织学和超微结构评估结果提示起源于涎腺导管细胞。肿瘤似乎起源于涎腺导管系统的细胞，这些细胞分化为具有神经内分泌或上皮特征的细胞。应进行电子显微镜检查以确定小细胞癌的类型，因为这可能具有预后意义。应采取积极治疗，因为主要唾液腺小细胞癌的预后似乎比支气管源性或喉小细胞癌更好。
