由柱[5]芳烃超分子开关控制的刺激响应性金属有机框架
Stimuli-responsive metal-organic frameworks gated by pillar[5]arene supramolecular switches.
作者信息
Tan Li-Li, Li Haiwei, Qiu Yu-Chen, Chen Dai-Xiong, Wang Xin, Pan Rui-Yi, Wang Yan, Zhang Sean Xiao-An, Wang Bo, Yang Ying-Wei
机构信息
State Key Laboratory of Supramolecular Structure and Materials , College of Chemistry , International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC) , Jilin University , 2699 Qianjin Street , Changchun 130012 , P. R. China . Email:
Key Laboratory of Cluster Science , Ministry of Education of China School of Chemistry , Beijing Institute of Technology , 5 South Zhongguancun Street , Beijing , 100081 , P. R. China . Email:
出版信息
Chem Sci. 2015 Mar 1;6(3):1640-1644. doi: 10.1039/c4sc03749a. Epub 2014 Dec 24.
Spurred on by recent advances in materials chemistry and drug delivery, a new stimuli-responsive theranostic hybrid platform, based on mechanized monodisperse nano metal-organic frameworks (NMOFs) gated by carboxylatopillar[5]arene (CP5) switches with bio-friendly pH-triggered cargo release capabilities, has been constructed for the first time. This nanoscale smart cargo delivery system showed pH- and/or competitive binding agent-triggered controlled cargo release with negligible premature release, large pore sizes for drug encapsulation, low cytotoxicity, good biodegradability and biocompatibility, and potential application in cell imaging, which offers a new tool in targeted drug delivery and the controlled release of therapeutic agents.
在材料化学和药物递送领域近期进展的推动下，首次构建了一种新型的刺激响应型治疗诊断混合平台，该平台基于由羧基柱[5]芳烃（CP5）开关门控的机械化单分散纳米金属有机框架（NMOF），具有生物友好的pH触发的货物释放能力。这种纳米级智能货物递送系统显示出pH和/或竞争性结合剂触发的可控货物释放，过早释放可忽略不计，具有用于药物封装的大孔径、低细胞毒性、良好的生物降解性和生物相容性，以及在细胞成像中的潜在应用，为靶向药物递送和治疗剂的控释提供了一种新工具。
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