State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, International Joint Research Laboratory of Nano-Micro Architecture Chemistry (NMAC), Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P. R. China.
Small. 2015 Aug;11(31):3807-13. doi: 10.1002/smll.201500155. Epub 2015 Apr 28.
A new theranostic nanoplatform, comprising of monodisperse zirconium metal-organic frameworks (MOFs) as drug carriers and carboxylatopillar[5]arene-based supramolecular switches as gating entities, is constructed, and controlled drug release triggered by bio-friendly Zn(2+) ions (abundant in synaptic vesicles) and auxiliary thermal stimulus is realized. This on-command drug delivery system exhibits large pore sizes for drug encapsulation, excellent biodegradability and biocompatibility, extremely low cytotoxicity and premature drug release, and superior dual-stimuli responsiveness, opening a new avenue in targeted drug delivery and controlled release of therapeutic agents, especially in the treatment of central nervous system diseases.
构建了一种新的治疗性纳米平台，由单分散的锆金属-有机骨架（MOFs）作为药物载体和基于羧酸柱[5]芳烃的超分子开关作为门控实体组成，并实现了由生物友好的 Zn(2+)离子（突触小泡中丰富）和辅助热刺激触发的控制药物释放。这种按需药物输送系统具有用于封装药物的大孔径、优异的生物降解性和生物相容性、极低的细胞毒性和过早的药物释放以及卓越的双重刺激响应性，为靶向药物输送和治疗剂的控制释放开辟了新途径，特别是在治疗中枢神经系统疾病方面。
