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糖尿病患者初级保健多学科风险评估和管理方案(RAMP-DM)的终生成本效益分析。

Cost-effectiveness of a primary care multidisciplinary Risk Assessment and Management Program for patients with diabetes mellitus (RAMP-DM) over lifetime.

机构信息

Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F., 161 Main Street, Ap Lei Chau Clinic, Ap Lei Chau, Hong Kong, Hong Kong.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 5/F, William MW Mong Block, 21 Sassoon Road, Hong Kong, Hong Kong.

出版信息

Endocrine. 2019 Feb;63(2):259-269. doi: 10.1007/s12020-018-1727-9. Epub 2018 Aug 28.

Abstract

PURPOSE

The multidisciplinary Risk Assessment and Management Program for patients with diabetes mellitus (RAMP-DM) was found to be cost-saving in comparison with usual primary care over 5 years' follow-up. This study aimed to estimate the cost-effectiveness of RAMP-DM over lifetime.

METHODS

We built a Discrete Event Simulation model to evaluate the cost-effectiveness of RAMP-DM over lifespan from public health service provider's perspective. Transition probabilities among disease states were extrapolated from a cohort of 17,140 propensity score matched participants in RAMP-DM and those under usual primary care over 5-year's follow-up. The mortality of patients with specific DM-related complications was estimated from a cohort of 206,238 patients with diabetes. Health preference and direct medical costs of DM patients referred to our previous studies among Chinese DM patients.

RESULTS

RAMP-DM individuals gained 0.745 QALYs and cost US$1404 less than those under usual care. The probabilistic sensitivity analysis found that RAMP-DM had 86.0% chance of being cost-saving compared to usual care under the assumptions and estimates used in the model. The probability of RAMP-DM being cost-effective compared to usual care would be over 99%, when the willingness to pay threshold is HK$20,000 (US$ 2564) or higher.

CONCLUSION

RAMP-DM added to usual primary care was cost-saving in managing people with diabetes over lifetime. These findings support the integration of RAMP-DM as part of routine primary care for all patients with diabetes.

摘要

目的

与 5 年随访期间的常规初级保健相比,多学科糖尿病患者风险评估和管理计划(RAMP-DM)被发现具有成本效益。本研究旨在估计 RAMP-DM 在终身内的成本效益。

方法

我们构建了一个离散事件模拟模型,从公共卫生服务提供者的角度评估 RAMP-DM 在寿命期间的成本效益。疾病状态之间的转移概率是从 RAMP-DM 中 17140 名倾向评分匹配参与者和 5 年随访期间常规初级保健下的参与者队列中推断出来的。特定糖尿病相关并发症患者的死亡率是从 206238 名糖尿病患者的队列中估计出来的。健康偏好和我们之前在中国糖尿病患者研究中引用的糖尿病患者的直接医疗费用。

结果

RAMP-DM 个体获得了 0.745 个 QALYs,比常规护理组节省了 1404 美元。概率敏感性分析发现,在模型中使用的假设和估计下,RAMP-DM 与常规护理相比,有 86.0%的可能性具有成本效益。当支付意愿阈值为 20000 港元(2564 美元)或更高时,RAMP-DM 比常规护理更具成本效益的概率将超过 99%。

结论

在管理糖尿病患者的终身中,将 RAMP-DM 添加到常规初级保健中具有成本效益。这些发现支持将 RAMP-DM 整合为所有糖尿病患者常规初级保健的一部分。

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