线粒体靶向序列可能形成两亲性螺旋。
Mitochondrial targeting sequences may form amphiphilic helices.
作者信息
von Heijne G
出版信息
EMBO J. 1986 Jun;5(6):1335-42. doi: 10.1002/j.1460-2075.1986.tb04364.x.
Abstract
Twenty three mitochondrial targeting sequences have been analysed with regard to their potential for forming amphiphilic helices. It is shown that most if not all of these sequences can be expected to form helices with high hydrophobic moments in a suitable environment. In the few cases studied so far, the segments of maximal hydrophobic moment coincide closely with 'critical' regions defined by deletions and point mutations.
摘要
对23个线粒体靶向序列形成两亲性螺旋的潜力进行了分析。结果表明，这些序列中的大多数（如果不是全部的话）在合适的环境中有望形成具有高疏水矩的螺旋。在目前研究的少数案例中，最大疏水矩的片段与由缺失和点突变定义的“关键”区域紧密重合。
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本文引用的文献
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Surface properties of an amphiphilic peptide hormone and of its analog: corticotropin-releasing factor and sauvagine.一种两亲性肽激素及其类似物的表面性质：促肾上腺皮质激素释放因子和蛙皮素。
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7070-4. doi: 10.1073/pnas.80.23.7070.
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Molecular cloning and nucleotide sequence of cDNA for mRNA of mitochondrial cytochrome P-450(SCC) of bovine adrenal cortex.牛肾上腺皮质线粒体细胞色素P-450（SCC）mRNA的cDNA分子克隆及核苷酸序列
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The hydrophobic moment detects periodicity in protein hydrophobicity.疏水矩检测蛋白质疏水性的周期性。
Proc Natl Acad Sci U S A. 1984 Jan;81(1):140-4. doi: 10.1073/pnas.81.1.140.
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A highly basic N-terminal extension of the mitochondrial matrix enzyme ornithine transcarbamylase from rat liver.大鼠肝脏线粒体基质酶鸟氨酸转氨甲酰酶的一个高度碱性的N端延伸序列。
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10
Analysis of membrane and surface protein sequences with the hydrophobic moment plot.利用疏水矩图分析膜蛋白和表面蛋白序列。
J Mol Biol. 1984 Oct 15;179(1):125-42. doi: 10.1016/0022-2836(84)90309-7.
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