College of Bioscience and Biotechnology, College of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan 410128, China.
Hunan Institute of Animal and Veterinary Science, Changsha, Changsha 410131, China.
Curr Pharm Des. 2018;24(24):2760-2764. doi: 10.2174/1381612824666180829100601.
In vitro and in vivo studies have revealed that Sanguinarine has antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory effects on tumor cells of a variety of cancers. Previous research showed that sanguinarine induced apoptosis (cell death) and/or antiproliferative while reducing tumor cell antiangiogenic and anti-invasive properties. This paper describes various sanguinarine anti-cancer mechanisms, including inhibition of erroneously-activated signal transduction pathways, apoptosis, and tumor cell proliferation inhibition.
体外和体内研究表明，血根碱对多种癌症的肿瘤细胞具有抗氧化、抗炎、促凋亡和生长抑制作用。先前的研究表明，血根碱诱导细胞凋亡（细胞死亡）和/或抗增殖，同时降低肿瘤细胞的抗血管生成和抗侵袭特性。本文描述了血根碱的各种抗癌机制，包括抑制错误激活的信号转导途径、凋亡和肿瘤细胞增殖抑制。
