Achkar Iman W, Mraiche Fatima, Mohammad Ramzi M, Uddin Shahab
Translational Research Institute, Hamad Medical Corporation, Doha, Qatar.
College of Pharmacy, Qatar University, Doha, Qatar.
Future Med Chem. 2017 Jun;9(9):933-950. doi: 10.4155/fmc-2017-0041. Epub 2017 Jun 21.
Sanguinarine (Sang) - a benzophenanthridine alkaloid extracted from Sanguinaria canadensis - exhibits antioxidant, anti-inflammatory, proapoptotic and growth inhibitory activities on tumor cells of various cancer types as established by in vivo and in vitro studies. Although the underlying mechanism of Sang antitumor activity is yet to be fully elucidated, Sang has displayed multiple biological effects, which remain to suggest its possible use in plant-derived treatments of human malignancies. This review covers the anticancer abilities of Sang including inhibition of aberrantly activated signal transduction pathways, induction of cell death and inhibition of cancer cell proliferation. It also highlights Sang-mediated inhibition of angiogenesis, inducing the expression of tumor suppressors, sensitization of cancer cells to standard chemotherapeutics to enhance their cytotoxic effects, while addressing the present need for further pharmacokinetic-based studies.
血根碱（Sang）——一种从加拿大血根草中提取的苯并菲啶生物碱——体内和体外研究表明，它对多种癌症类型的肿瘤细胞具有抗氧化、抗炎、促凋亡和生长抑制活性。尽管血根碱抗肿瘤活性的潜在机制尚未完全阐明，但它已显示出多种生物学效应，这表明其可能用于人类恶性肿瘤的植物源治疗。本综述涵盖了血根碱的抗癌能力，包括抑制异常激活的信号转导通路、诱导细胞死亡和抑制癌细胞增殖。它还强调了血根碱介导的血管生成抑制、肿瘤抑制因子的表达诱导、癌细胞对标准化疗药物的致敏以增强其细胞毒性作用，同时也指出了目前基于药代动力学的进一步研究的必要性。
