College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Anticancer Agents Med Chem. 2021 Oct 28;21(16):2100-2110. doi: 10.2174/1871520621666210126091512.
Sanguinarine, a kind of benzophenanthridine alkaloid, is a natural compound with potential development value for its anticancer activity. Hundreds of studies have been carried out in vivo or in vitro, trying to make it feasible for the anticancer clinic medication of sanguinarine. However, sanguinarine was branded as a toxicant or even a carcinogen according to some toxicological experiments and cancer investigations.
Aiming at safety and effectiveness of sanguinarine, this article reviews the extant information on present studies of sanguinarine, and both anticancer carcinogenesis mechanism details are summarized. The future potential research directions of this valued compound are also discussed to provide reference for future drugs development.
PubMed, Web of Science, CNKI and WanFang databases were used to search current studies and experimental researches about anticancer effect or carcinogenic information of sanguinarine.
Our results indicated that sanguinarine exhibited anticancer effect through anti-proliferation, anti-invasion, anti-angiogenesis and apoptosis within cancer lesion. Also, many clinical investigations indicated that sanguinarine and its related products might be associated to pre-carcinoma within oral or skin potentially.
Sanguinarine is a natural compound with good development value for its potent anticancer activity; however, its carcinogenesis effect should also be taken seriously. Studies on structural modification and analogue design should be carried out to improve its safety and efficiency in the future.
血根碱是一种苯并菲啶生物碱，具有抗癌活性，是一种具有潜在开发价值的天然化合物。已有数百项体内或体外研究试图使其成为血根碱抗癌临床用药成为可能。然而，根据一些毒理学实验和癌症研究，血根碱被标记为有毒物质甚至致癌物。
针对血根碱的安全性和有效性，本文综述了目前对血根碱的研究信息，总结了其抗癌致癌机制的详细信息。还讨论了该有价值化合物的未来潜在研究方向，为未来药物开发提供参考。
使用 PubMed、Web of Science、CNKI 和万方数据库搜索关于血根碱抗癌作用或致癌信息的当前研究和实验研究。
我们的结果表明，血根碱通过在肿瘤病变部位的抗增殖、抗侵袭、抗血管生成和凋亡来发挥抗癌作用。此外，许多临床研究表明，血根碱及其相关产品可能与口腔或皮肤的潜在癌前病变有关。
血根碱是一种具有良好开发价值的天然化合物，具有很强的抗癌活性；然而，其致癌作用也应引起重视。未来应开展结构修饰和类似物设计的研究，以提高其安全性和效率。
