Ikenouchi Junichi
a Department of Biology, Faculty of Sciences , Kyushu University , Fukuoka , Nishi-ku , Japan.
b AMED-PRIME, Japan Agency for Medical Research and Development , Tokyo , Japan.
Tissue Barriers. 2018;6(2):1-8. doi: 10.1080/21688370.2018.1502531. Epub 2018 Aug 29.
Epithelial cells have characteristic membrane domains. Identification of membrane proteins playing an important role in these membrane domains has progressed and numerous studies have been performed on the functional analysis of these membrane proteins. On the other hand, the precise roles of membrane lipids in the organization of these membrane domains are largely unknown. Historically, the concept of lipid raft arose from the analysis of lipid composition of the apical membrane, and it can be said that epithelial cells are an optimal experimental model for elucidating the functions of lipids. In this review, I discuss the role of lipids in the formation of epithelial polarity and in the formation of cell membrane structures of epithelial cells such as microvilli in the apical domain, cell-cell adhesion apparatus in the lateral domain and cell-matrix adhesion in the basal domain.
上皮细胞具有特征性的膜结构域。在这些膜结构域中发挥重要作用的膜蛋白的鉴定工作已经取得进展，并且已经对这些膜蛋白进行了大量的功能分析研究。另一方面，膜脂在这些膜结构域组织中的精确作用在很大程度上尚不清楚。从历史上看，脂筏的概念源于对顶端膜脂质组成的分析，可以说上皮细胞是阐明脂质功能的理想实验模型。在这篇综述中，我将讨论脂质在上皮极性形成以及上皮细胞细胞膜结构形成中的作用，这些结构包括顶端结构域的微绒毛、侧面结构域的细胞间黏附装置以及基底结构域的细胞与基质黏附。
