1 Department of Cardiology, Affiliated Hospital of Qinghai University, China.
2 Department of Oncology, Affiliated Hospital of Qinghai University, China.
Eur J Prev Cardiol. 2018 Nov;25(17):1864-1872. doi: 10.1177/2047487318795194. Epub 2018 Aug 30.
Many cohort studies within the past few decades have shown the protective effect of leisure-time physical activity on cardiovascular mortality. To summarise the evidence from prospective cohort studies on the relationship between the amount of leisure-time physical activity and the risk of cardiovascular mortality, a dose-response meta-analysis was conducted in this study.
Electronic databases, including PubMed and Embase databases, Scopus and Cochrane Library, were systemically retrieved by two investigators from inception to 14 June 2018 for related studies. The maximum adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted, and a dose-response analysis was conducted using the restricted cubic splines. Finally, a total of 44 studies comprising 1,584,181 participants was enrolled into this meta-analysis. The HRs of cardiovascular mortality for moderate and high leisure-time physical activity were 0.77 (95% CI 0.74-0.81) and 0.73 (95% CI 0.69-0.77), respectively. Among these 44 studies, 19 were eligible for the dose-response meta-analysis, which suggested a linear negative correlation of leisure-time physical activity with cardiovascular mortality, regardless of age, gender and the presence of underlying cardiovascular disease or not.
Leisure-time physical activity shows a linear negative correlation with the risk of cardiovascular mortality regardless of age, gender and the presence of cardiovascular disease or not. However, the cardiovascular benefits of leisure-time physical activity is decreased for those aged over 65 years or those with a history of cardiovascular disease. Moreover, leisure-time physical activity displays more cardiovascular benefits to people followed up for over 10 years than to those followed up for less than 10 years. Besides, high-intensity leisure-time physical activity has more obvious cardiovascular benefits than those of moderate-intensity leisure-time physical activity.
过去几十年的许多队列研究表明，休闲时间体力活动对心血管死亡率有保护作用。为了总结前瞻性队列研究关于休闲时间体力活动量与心血管死亡率风险之间关系的证据，本研究进行了剂量-反应荟萃分析。
两名研究者从建库起至 2018 年 6 月 14 日，系统地检索了电子数据库，包括 PubMed 和 Embase 数据库、Scopus 和 Cochrane 图书馆，以获取相关研究。提取了最大调整后的危险比（HRs）和 95%置信区间（CIs），并使用限制立方样条进行了剂量-反应分析。最终，共有 44 项研究，共纳入 1584181 名参与者纳入了这项荟萃分析。中高强度休闲时间体力活动与心血管死亡率的 HR 分别为 0.77（95%CI 0.74-0.81）和 0.73（95%CI 0.69-0.77）。在这 44 项研究中，有 19 项符合剂量-反应荟萃分析的条件，结果表明，无论年龄、性别以及是否存在心血管疾病，休闲时间体力活动与心血管死亡率呈线性负相关。
无论年龄、性别以及是否存在心血管疾病，休闲时间体力活动与心血管死亡率的风险呈线性负相关。然而，对于年龄超过 65 岁或有心血管疾病史的人来说，休闲时间体力活动的心血管益处会降低。此外，对于随访时间超过 10 年的人群，休闲时间体力活动对心血管的益处比随访时间少于 10 年的人群更大。此外，高强度的休闲时间体力活动比中等强度的休闲时间体力活动对心血管有更明显的益处。
