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累及前庭和牙槽的透明细胞肌上皮癌:1例罕见病例报告并文献复习

Clear cell myoepithelial carcinoma involving vestibule and alveolus: A rare case report with review of literature.

作者信息

Gupta Anish A, Khare Pooja, Jain Megha, Handa Hina

机构信息

Department of Oral Pathology and Microbiology, People's Dental Academy, Bhopal, Madhya Pradesh, India.

Department of Oral Medicine and Radiology, People's Dental Academy, Bhopal, Madhya Pradesh, India.

出版信息

J Oral Maxillofac Pathol. 2018 May-Aug;22(2):245-248. doi: 10.4103/jomfp.JOMFP_10_18.

DOI:10.4103/jomfp.JOMFP_10_18
PMID:30158779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6097389/
Abstract

Myoepithelial carcinomas (MCs) are difficult to distinguish from their benign counterpart due to diverse morphology. This neoplasm was introduced by Stromeyer . in 1975. They comprise of <2% of all salivary gland carcinomas involving most commonly major salivary glands and are characterized by differentiation of tumor cells into myoepithelial cells. The cells may present as epithelioid, plasmacytoid, spindle, clear, stellate and mixed type predominantly. Literature search revealed very few cases reported as clear cell variant of MC. Here, we report a case of clear cell MC involving buccal vestibule extending up to alveolus. The diagnosis was confirmed, and the patient was surgically treated.

摘要

肌上皮癌(MCs)因其形态多样,难以与良性对应物区分开来。这种肿瘤由斯特罗迈尔于1975年首次提出。它们占所有涎腺癌的比例不到2%,最常累及大涎腺,其特征是肿瘤细胞向肌上皮细胞分化。细胞主要表现为上皮样、浆细胞样、梭形、透明、星状及混合型。文献检索显示,报道为MC透明细胞变体的病例非常少。在此,我们报告一例累及颊前庭并延伸至牙槽的透明细胞MC病例。诊断得到证实,患者接受了手术治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/14c710fe8c65/JOMFP-22-245-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/8d0be82667b7/JOMFP-22-245-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/e89200a29bec/JOMFP-22-245-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/ac6892e09fad/JOMFP-22-245-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/6c8350fa7a83/JOMFP-22-245-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/1ce24e6aed1d/JOMFP-22-245-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/14c710fe8c65/JOMFP-22-245-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/8d0be82667b7/JOMFP-22-245-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/e89200a29bec/JOMFP-22-245-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/ac6892e09fad/JOMFP-22-245-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/6c8350fa7a83/JOMFP-22-245-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/1ce24e6aed1d/JOMFP-22-245-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a46/6097389/14c710fe8c65/JOMFP-22-245-g006.jpg

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本文引用的文献

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Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.多维度基因组分析肌上皮癌,鉴定出常见的致癌基因融合。
Nat Commun. 2017 Oct 30;8(1):1197. doi: 10.1038/s41467-017-01178-z.
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Myoepithelial cell carcinoma of the oral cavity: A case report and review of literature.口腔肌上皮细胞癌:一例报告并文献复习
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Myoepithelial Carcinoma of the Salivary Glands: A Clinicopathologic Study of 29 Patients.涎腺肌上皮癌:29例患者的临床病理研究
J Oral Maxillofac Surg. 2015 Oct;73(10):1938-45. doi: 10.1016/j.joms.2015.03.054. Epub 2015 Apr 1.
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Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component.显示EWSR1重排的涎腺透明细胞肌上皮癌:94例具有显著透明细胞成分的涎腺肿瘤的分子分析
Am J Surg Pathol. 2015 Mar;39(3):338-48. doi: 10.1097/PAS.0000000000000364.
6
Myoepithelial carcinoma of buccal mucosa: A rare tumor.颊黏膜肌上皮癌:一种罕见肿瘤。
Contemp Clin Dent. 2014 Apr;5(2):247-51. doi: 10.4103/0976-237X.132372.
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Clear cell myoepithelial carcinoma in the base of the tongue: Case report and review of the literature.舌根部透明细胞肌上皮癌:病例报告及文献复习
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Myoepithelial carcinoma of the salivary glands: a clinicopathologic study of 51 cases in a tertiary cancer center.涎腺肌上皮癌:三级癌症中心51例临床病理研究
Arch Otolaryngol Head Neck Surg. 2010 Jul;136(7):702-12. doi: 10.1001/archoto.2010.104.
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Clear cell myoepithelial carcinoma of minor salivary gland: a case report.小唾液腺透明细胞肌上皮癌 1 例报告。
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Clear-cell myoepithelial carcinoma of the salivary glands: a clinicopathologic, immunohistochemical, and ultrastructural study of two cases involving the submandibular gland with review of the literature.涎腺透明细胞肌上皮癌:两例累及下颌下腺病例的临床病理、免疫组化及超微结构研究并文献复习
Pathol Res Pract. 2008;204(5):335-44. doi: 10.1016/j.prp.2007.11.006. Epub 2008 Jan 18.