Ingle Yashwant, Shah Amisha Ashokkumar, Kheur Supriya, Routaray Samapika
Department of Dentistry, Yashwantrao Chavan Memorial Hospital, Pimpri, Pune, India.
Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences and Research Center, Pune, India.
J Oral Maxillofac Pathol. 2014 Sep-Dec;18(3):472-7. doi: 10.4103/0973-029X.151360.
Myoepithelial carcinoma (MC) is a malignant salivary gland neoplasm whose tumor cells demonstrate cytologic differentiation toward myoepithelial cells and lack ductal or acinar differentiation. It is a relatively rare tumor and many a times remains undiagnosed because of histopathological heterogeneity. It represents about 0.4-0.6% of all salivary gland tumors and 1.2-1.5% of carcinomas. It occurs predominantly in the parotid gland with a mean age of presentation being 55 years (range 14-86) with no sex predilection. MC appears to be a low grade malignancy when arising in a pleomorphic adenoma, but tends to be more aggressive and has a higher metastatic potential when arising de novo. The clinical behavior of MC is variable and there are no pathologic features that correlate with patients' outcome. Most tumors that display marked cytologic atypia, high mitotic activity and necrosis tend to behave aggressively. The current case is of a 42-year-old male with recurrent tumor mass in the mandibular right posterior region. The purpose of this article was to describe the clinicopathological and immunohistochemical features of intraoral MC and to discuss review of literature of this rare tumor.
肌上皮癌（MC）是一种恶性唾液腺肿瘤，其肿瘤细胞表现出向肌上皮细胞的细胞学分化，缺乏导管或腺泡分化。它是一种相对罕见的肿瘤，由于组织病理学异质性，很多时候仍未被诊断出来。它约占所有唾液腺肿瘤的0.4 - 0.6%，占癌的1.2 - 1.5%。它主要发生在腮腺，平均发病年龄为55岁（范围14 - 86岁），无性别倾向。当肌上皮癌发生于多形性腺瘤时似乎为低级别恶性肿瘤，但原发时往往更具侵袭性且转移潜能更高。肌上皮癌的临床行为多变，且没有与患者预后相关的病理特征。大多数表现出明显细胞学异型性、高有丝分裂活性和坏死的肿瘤往往行为侵袭性较强。本病例为一名42岁男性，下颌右后区域有复发性肿瘤肿块。本文的目的是描述口腔内肌上皮癌的临床病理和免疫组化特征，并对这种罕见肿瘤的文献进行综述。
