New insights into MTORC1 amino acid sensing and activation.
作者信息
Gatica Damián, Klionsky Daniel J
机构信息
Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, USA.
出版信息
Biotarget. 2017 May;1. doi: 10.21037/biotarget.2017.04.01. Epub 2017 May 16.
Abstract
摘要
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本文引用的文献
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mTOR Signaling in Growth, Metabolism, and Disease.生长、代谢及疾病中的mTOR信号传导
Cell. 2017 Apr 6;169(2):361-371. doi: 10.1016/j.cell.2017.03.035.
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Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.溶酶体膜蛋白SLC38A9对氨基酸依赖性的mTORC1调控
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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.代谢。溶酶体氨基酸转运蛋白SLC38A9向mTORC1发出精氨酸充足的信号。
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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.溶质载体家族38成员9（SLC38A9）是溶酶体氨基酸传感机制的一个组成部分，该机制控制哺乳动物雷帕霉素靶蛋白复合物1（mTORC1）。
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The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.抑瘤素 F 肿瘤抑制因子是 RagC/D GTP 酶的 GAP，可将氨基酸水平信号传递给 mTORC1。
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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.mTORC1 通过一种需要液泡 H(+)-ATP 酶的内外机制感知溶酶体氨基酸。
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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.Ragulator-Rag 复合物将 mTORC1 靶向到溶酶体表面，并且对于其被氨基酸激活是必需的。
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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.Rag GTP酶结合 Raptor 并介导氨基酸信号传导至 mTORC1。
Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22.
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Genes Dev. 2003 Aug 1;17(15):1829-34. doi: 10.1101/gad.1110003. Epub 2003 Jul 17.
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