Center for Bio-Integrated Electronics , Northwestern University , Evanston , Illinois 60208 , United States.
Department of Mechanical Science and Engineering , University of Illinois at Urbana-Champaign , Urbana , Illinois 61801 , United States.
ACS Nano. 2018 Oct 23;12(10):9721-9732. doi: 10.1021/acsnano.8b04513. Epub 2018 Sep 10.
Foundry-compatible materials and processing approaches serve as the foundations for advanced, active implantable microsystems that can dissolve in biofluids into biocompatible reaction products, with broad potential applications in biomedicine. The results reported here include in vitro studies of the dissolution kinetics and nanoscale bioresorption behaviors of device-grade thin films of Si, SiN , SiO, and W in the presence of dynamic cell cultures via atomic force microscopy and X-ray photoemission spectroscopy. In situ investigations of cell-extracellular mechanotransduction induced by cellular traction provide insights into the cytotoxicity of these same materials and of microcomponents formed with them using foundry-compatible processes, indicating potential cytotoxicity elicited by W at concentrations greater than 6 mM. The findings are of central relevance to the biocompatibility of modern Si-based electronics technologies as active, bioresorbable microsystems that interface with living tissues.
铸造兼容的材料和加工方法是先进的、可在生物流体中溶解为生物相容性反应产物的有源植入式微系统的基础，在生物医学中有广泛的潜在应用。这里报道的结果包括通过原子力显微镜和 X 射线光电子能谱，在动态细胞培养物存在的情况下，对器件级 Si、SiN、SiO 和 W 薄膜的溶解动力学和纳米级生物再吸收行为的体外研究。通过细胞牵引力对细胞-细胞外机械转导的原位研究，深入了解了这些相同材料以及使用铸造兼容工艺形成的微组件的细胞毒性，表明浓度大于 6 mM 的 W 会引起潜在的细胞毒性。这些发现对于作为与活组织接口的有源、可生物吸收的微系统的现代基于 Si 的电子技术的生物相容性具有核心意义。
