Demir S, Ede H, Kaplan M, Yavuz F, Yucel C, Kurt I H
Bratisl Lek Listy. 2018;119(7):421-424. doi: 10.4149/BLL_2018_076.
The structural and compositional changes in the myocardium seem to have a major role in the development of heart failure (HF).Imbalance between production and degradation in extracellular collagen results in increase of collagen synthesis biomarkers in the circulation as the carboxy-terminal propeptide of type I procollagen (PIP). Here we aimed to determine role of PIP in the diagnosis of chronic HF.
87 patients with HF group and 80 healthy subjects were enrolled into the study. Echocardiographic examination was performed.At the beginning of the study, serum B type natriuretic peptide (BNP), PIP, high sensitive C-reactive protein (hs-CRP) were measured . The subjects were followed for one year then after.
Average PIP value of HF group was significantly higher than that of the control group (p < 0.001). Both hs-CRP and BNP values were well correlated to PIP values (p < 0.001). In the HF group, PIP value of patients who died at the end of one year was similar to that of patients who survived at the end of first year.
PIP may not mirror acute events in follow-up of chronic heart failure but it is a very beneficial biomarker in diagnosis of low-LVEF heart failure with high sensitivity and specificity (Tab. 2, Fig. 1, Ref. 16).
心肌的结构和成分变化似乎在心力衰竭（HF）的发展中起主要作用。细胞外胶原蛋白的生成与降解失衡会导致循环中胶原蛋白合成生物标志物增加，如I型前胶原羧基末端前肽（PIP）。我们旨在确定PIP在慢性HF诊断中的作用。
87例HF患者和80名健康受试者纳入研究。进行超声心动图检查。研究开始时，测量血清B型利钠肽（BNP）、PIP、高敏C反应蛋白（hs-CRP）。之后对受试者随访一年。
HF组的平均PIP值显著高于对照组（p<0.001）。hs-CRP和BNP值均与PIP值高度相关（p<0.001）。在HF组中，一年末死亡患者的PIP值与第一年末存活患者的相似。
在慢性心力衰竭的随访中，PIP可能无法反映急性事件，但它是诊断低左室射血分数心力衰竭的一种非常有益的生物标志物，具有高敏感性和特异性（表2，图1，参考文献16）。
