Francis M J, Black L
J Hyg (Lond). 1986 Jun;96(3):501-11. doi: 10.1017/s0022172400066304.
Four groups of sows were inoculated, either once or twice, with O1BFS 1860 foot and mouth disease oil-emulsion vaccine during pregnancy and samples of serum, for analysis, were collected at intervals for greater than 300 days. The pregnant sows responded well to vaccination regardless of their state of gestation. Single vaccination produced protective levels of antibody (greater than 1.53 log10SN50) in 3 out of 4 sows while double vaccination produced protective levels in all 6 sows tested. Anti-FMD IgM antibodies could be detected for 40-60 days after vaccination or revaccination. Anti-FMD IgG antibodies appeared within 10 days of vaccination and persisted, in each sow, for the duration of the study. The anti-FMD IgA response observed was less easy to characterize due to significant animal to animal variation. Although there was no evidence of a fall in the neutralizing antibody titres over one year post vaccination the anti-FMD IgG antibody population did show signs of a change in its heterogeneity and avidity.
四组母猪在怀孕期间接种了O1BFS 1860口蹄疫油乳剂疫苗，接种一次或两次，并在300多天的时间里定期采集血清样本进行分析。无论妊娠状态如何，怀孕母猪对疫苗接种反应良好。单次接种使4头母猪中的3头产生了保护性抗体水平（大于1.53 log10SN50），而两次接种使所有6头受试母猪都产生了保护性水平。接种或再次接种疫苗后40 - 60天可检测到抗口蹄疫IgM抗体。抗口蹄疫IgG抗体在接种后10天内出现，并在每头母猪体内持续到研究结束。由于动物个体之间存在显著差异，观察到的抗口蹄疫IgA反应较难描述特征。尽管没有证据表明接种疫苗一年后中和抗体滴度下降，但抗口蹄疫IgG抗体群体确实显示出其异质性和亲和力发生了变化的迹象。
