单纯疱疹病毒（HSV）特异性人类T细胞克隆可识别由重组痘苗病毒表达的HSV糖蛋白D。
Herpes simplex virus (HSV)-specific human T-cell clones recognize HSV glycoprotein D expressed by a recombinant vaccinia virus.
作者信息
Zarling J M, Moran P A, Lasky L A, Moss B
出版信息
J Virol. 1986 Aug;59(2):506-9. doi: 10.1128/JVI.59.2.506-509.1986.
Abstract
Human cytotoxic T-cell (CTL) clones that lyse autologous cells infected with herpes simplex virus (HSV) type 1 or 2 were generated by stimulating lymphocytes with a recombinant vaccinia virus (recombinant vaccinia-gD-1 virus) that expresses HSV type 1 glycoprotein D (gD-1). Furthermore, CTL clones generated with HSV type 1 or with cloned gD-1 lysed autologous cells infected with the recombinant vaccinia-gD-1 virus. Our findings thus showed that gD serves as a target antigen for human CTLs and that a recombinant vaccinia-gD virus activates HSV-specific human CTL.
摘要
通过用表达1型单纯疱疹病毒（HSV）糖蛋白D（gD-1）的重组痘苗病毒（重组痘苗-gD-1病毒）刺激淋巴细胞，产生了可裂解被1型或2型HSV感染的自体细胞的人细胞毒性T细胞（CTL）克隆。此外，用1型HSV或克隆的gD产生的CTL克隆可裂解被重组痘苗-gD-1病毒感染的自体细胞。因此，我们的研究结果表明，gD可作为人CTL的靶抗原，并且重组痘苗-gD病毒可激活HSV特异性人CTL。
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