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猿猴病毒40主要结构蛋白的DNA结合特性

DNA-binding properties of the major structural protein of simian virus 40.

作者信息

Soussi T

出版信息

J Virol. 1986 Sep;59(3):740-2. doi: 10.1128/JVI.59.3.740-742.1986.

DOI:10.1128/JVI.59.3.740-742.1986
PMID:3016336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC253252/
Abstract

We investigated whether the VP1 protein of simian virus 40 binds to DNA. In vitro DNA-binding experiments clearly indicate that VP1 bound strongly to double-stranded and single-stranded DNA, with a higher affinity for the latter; additional experiments show that VP1 did not bind to a specific sequence of simian virus 40 DNA.

摘要

我们研究了猴病毒40的VP1蛋白是否与DNA结合。体外DNA结合实验清楚地表明，VP1与双链和单链DNA都有强烈结合，对后者的亲和力更高；进一步的实验表明，VP1不与猴病毒40 DNA的特定序列结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8b/253252/5d2de2ed786c/jvirol00108-0217-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8b/253252/87c626bcb171/jvirol00108-0216-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8b/253252/a625e1781404/jvirol00108-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8b/253252/f33174a8f05a/jvirol00108-0217-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8b/253252/5d2de2ed786c/jvirol00108-0217-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8b/253252/87c626bcb171/jvirol00108-0216-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8b/253252/a625e1781404/jvirol00108-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8b/253252/f33174a8f05a/jvirol00108-0217-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a8b/253252/5d2de2ed786c/jvirol00108-0217-c.jpg

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1
DNA-binding properties of the major structural protein of simian virus 40.猿猴病毒40主要结构蛋白的DNA结合特性
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本文引用的文献

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Simian virus 40 morphogenetic pathway. An analysis of assembly-defective tsB201 DNA protein complexes.猴病毒40形态发生途径。对装配缺陷型tsB201 DNA蛋白复合物的分析。
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Absence of nucleosomes in a histone-containing nucleoprotein complex obtained by dissociation of purified SV40 virions.通过纯化的SV40病毒粒子解离获得的含组蛋白核蛋白复合物中核小体的缺失。
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How Simian Virus 40 Hijacks the Intracellular Protein Trafficking Pathway to Its Own Benefit … and Ours.猴病毒 40 如何劫持细胞内蛋白质运输途径为己所用……也为我们所用。
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Characterization of self-assembled virus-like particles of Merkel cell polyomavirus.默克尔细胞多瘤病毒自组装病毒样颗粒的特性分析
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Chromosome-protein interactions in polyomavirus virions.多瘤病毒病毒粒子中的染色体-蛋白质相互作用。
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Cellular transcription factor Sp1 recruits simian virus 40 capsid proteins to the viral packaging signal, ses.细胞转录因子Sp1将猿猴病毒40衣壳蛋白募集到病毒包装信号序列ses。
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8
Simian virus 40 Vp1 DNA-binding domain is functionally separable from the overlapping nuclear localization signal and is required for effective virion formation and full viability.猴病毒40 Vp1的DNA结合结构域在功能上可与重叠的核定位信号分离，是有效病毒粒子形成和完全存活所必需的。
J Virol. 2001 Aug;75(16):7321-9. doi: 10.1128/JVI.75.16.7321-7329.2001.
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DNA encapsidation by viruslike particles assembled in insect cells from the major capsid protein VP1 of B-lymphotropic papovavirus.由B淋巴细胞嗜性乳头多瘤病毒的主要衣壳蛋白VP1在昆虫细胞中组装而成的病毒样颗粒对DNA的包装。
J Virol. 1996 Nov;70(11):7517-26. doi: 10.1128/JVI.70.11.7517-7526.1996.
10
Association with capsid proteins promotes nuclear targeting of simian virus 40 DNA.与衣壳蛋白的结合促进了猿猴病毒40 DNA的核靶向。
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Efficient transcription of a compact nucleoprotein complex isolated from purified simian virus 40 virions.从纯化的猴病毒40病毒粒子中分离出的紧密核蛋白复合物的高效转录。
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Differential affinities of simian virus 40 large tumor antigen for DNA.猴病毒40大肿瘤抗原对DNA的差异亲和力。
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Stable association of viral protein VP1 with simian virus 40 DNA.病毒蛋白VP1与猴病毒40 DNA的稳定结合。
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Pattern of protein synthesis in monkey cells infected by simian virus 40.被猴病毒40感染的猴细胞中的蛋白质合成模式。
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P53-transformation-related protein: kinetics of synthesis and accumulation in SV40-infected primary mouse kidney cell cultures.P53转化相关蛋白：在感染SV40的原代小鼠肾细胞培养物中的合成与积累动力学
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