鼠白血病病毒长末端重复序列能够以细胞类型特异性的方式增强基因活性。
Murine leukemia virus long terminal repeat sequences can enhance gene activity in a cell-type-specific manner.
作者信息
Yoshimura F K, Davison B, Chaffin K
出版信息
Mol Cell Biol. 1985 Oct;5(10):2832-5. doi: 10.1128/mcb.5.10.2832-2835.1985.
Abstract
We tested the ability of sequences in the long terminal repeat (LTR) of a mink cell focus-forming (MCF) murine leukemia virus to function as an enhancer in a cell-type-specific manner. In a stable transformation assay, the MCF or Akv LTR and the simian virus 40 enhancer had similar activities in murine fibroblasts. In contrast, the MCF LTR had a significantly greater activity in murine T lymphoid cells than did either the simian virus 40 enhancer or the Akv LTR.
摘要
我们测试了水貂细胞灶形成（MCF）鼠白血病病毒长末端重复序列（LTR）中的序列以细胞类型特异性方式作为增强子发挥功能的能力。在稳定转化试验中，MCF或Akv LTR与猿猴病毒40增强子在鼠成纤维细胞中具有相似的活性。相比之下，MCF LTR在鼠T淋巴细胞中的活性显著高于猿猴病毒40增强子或Akv LTR。
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