Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts.
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts.
J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1316-1321. doi: 10.1093/gerona/gly199.
Progressive resistance training (PRT) is consistently shown to improve muscle strength in older adults. The efficacy of PRT to improve muscle fatigue in older adults with demonstrated mobility limitations remains unclear.
Mobility-limited (Short Physical Performance Battery [SPPB] ≤ 9) older adults (age 70-92 years) were recruited for this study and randomized to either PRT or home-based flexibility (FLEX) 3 d/wk for 12 weeks. Muscle fatigue and strength outcomes were assessed at baseline and 12 weeks. The primary outcome was torque capacity, a composite measure of strength and fatigue, defined as the sum of peak torques from an isokinetic fatigue test.
Seventy participants were randomized (mean [SD] age 78.9 [5.4] years; 60% female; mean [SD] SPPB 7.5 [1.6]). At follow-up, the PRT group improved significantly in torque capacity, mean between-group difference (95% confidence interval) 466.19 (138.4, 793.97) Nm (p = .006), and maximal strength 127.3 (60.96, 193.61) Nm (p = .0003), when compared with FLEX group. Neither group demonstrated significant changes in muscle fatigue or torque variability.
Twelve weeks of PRT improved torque capacity, as well as strength in mobility-limited older adults. These results demonstrate PRT improves multiple age-related muscular impairments.
渐进式抗阻训练(PRT)已被证实可改善老年人的肌肉力量。对于有明确活动能力限制的老年人,PRT 改善肌肉疲劳的效果尚不清楚。
本研究招募了活动能力受限(短体适能测试[SPPB]≤9)的老年人(年龄 70-92 岁),并将其随机分为 PRT 组或家庭基础柔韧性(FLEX)组,每周 3 天,持续 12 周。在基线和 12 周时评估肌肉疲劳和力量的结果。主要结局指标是扭矩能力,这是力量和疲劳的综合衡量指标,定义为等速疲劳测试中峰值扭矩的总和。
70 名参与者被随机分组(平均[标准差]年龄 78.9[5.4]岁;60%为女性;平均[标准差]SPPB 7.5[1.6])。随访时,PRT 组的扭矩能力显著提高,组间平均差异(95%置信区间)为 466.19(138.4,793.97)Nm(p =.006),最大力量提高 127.3(60.96,193.61)Nm(p =.0003),与 FLEX 组相比。两组在肌肉疲劳或扭矩变异性方面均无显著变化。
12 周的 PRT 可提高活动能力受限的老年人的扭矩能力和力量。这些结果表明 PRT 可改善多种与年龄相关的肌肉损伤。