Reznikoff G A, Manaker S, Rhodes C H, Winokur A, Rainbow T C
Neurology. 1986 Aug;36(8):1067-73. doi: 10.1212/wnl.36.8.1067.
Little information is currently available on the localization of noradrenergic systems in the human CNS. We used quantitative autoradiography with [125I] iodopindolol to examine beta-adrenergic receptors in postmortem human brain. The concentration of beta-receptors was highest in all subfields of the hippocampus, followed by cerebellum, and then thalamic nuclei, basal ganglia, midbrain, and cerebral cortex. Low levels were found in white matter and hypothalamus. This distribution differed from the distribution of beta-receptors reported in membrane homogenates of human brain and also from the distribution of beta-receptors in rat brain determined by autoradiography. The similarities and differences between the distribution of beta-receptors in the human and rat brains may have implications regarding the role of norepinephrine in the CNS of these two species.
目前关于去甲肾上腺素能系统在人类中枢神经系统中的定位信息很少。我们使用[125I]碘吲哚洛尔进行定量放射自显影，以检测死后人类大脑中的β-肾上腺素能受体。β-受体浓度在海马体的所有亚区中最高，其次是小脑，然后是丘脑核、基底神经节、中脑和大脑皮层。在白质和下丘脑中发现的水平较低。这种分布不同于人类脑膜匀浆中报道的β-受体分布，也不同于通过放射自显影确定的大鼠大脑中β-受体的分布。人类和大鼠大脑中β-受体分布的异同可能对去甲肾上腺素在这两个物种中枢神经系统中的作用有影响。
