Department of Biology, The Pennsylvania State University, State College, Pennsylvania 16802-5301
Genetics. 2018 Sep;210(1):3-13. doi: 10.1534/genetics.118.301084.
The concept of synteny, or conservation of genes on the same chromosome, traces its origins to the early days of genetics. This discovery emerged from comparisons of linkage maps from different species of with the goal of understanding the process of speciation. H. J. Muller published a landmark article entitled , where he synthesized genetic and physical map data and proposed a model of speciation and chromosomal gene content conservation. These models have withstood the test of time with the advent of molecular genetic analysis from protein to genome level variation. Muller's ideas provide a framework to begin to answer questions about the evolutionary forces that shape the structure of the genome.
基因在同一条染色体上连锁的概念，或者说基因的同线性，可以追溯到遗传学的早期。这一发现源于对不同物种的连锁图谱的比较，目的是了解物种形成的过程。H. J. Muller 发表了一篇题为 的里程碑式的文章，他综合了遗传和物理图谱数据，并提出了一个物种形成和染色体基因内容保守的模型。随着从蛋白质到基因组水平变化的分子遗传分析的出现，这些模型经受住了时间的考验。Muller 的思想为开始回答有关塑造基因组结构的进化力量的问题提供了一个框架。
