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绿微藻杜氏盐藻可降低氧化应激并诱导人体细胞修复机制。

The green microalga Tetraselmis suecica reduces oxidative stress and induces repairing mechanisms in human cells.

机构信息

Integrative Marine Ecology Department, Stazione Zoologica Anton Dohrn, Villa Comunale, Naples 80121, Italy.

University of Naples "Federico II", Department of Veterinary Medicine and Animal Production, Via Federico Delpino 1, Naples 80137, Italy.

出版信息

Sci Rep. 2017 Jan 24;7:41215. doi: 10.1038/srep41215.

DOI:10.1038/srep41215
PMID:28117410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5259714/
Abstract

Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E (PGE) levels in cells damaged by HO and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm) indicating a potential cosmeceutical activity of this microalgal species.

摘要

绿藻含有许多具有抗氧化和保护活性的活性色素，如类胡萝卜素。在这里，我们研究了一种含有高水平类胡萝卜素的海洋绿藻塔苏斯氏藻的乙醇/水提取物的生物学活性，这些类胡萝卜素包括叶黄素、 violaxanthin、新黄质、玉米黄质和 loroxanthin 酯。该提取物在人肺癌细胞系（A549）中具有很强的抗氧化和修复活性，这表现为脱氢胆固醇还原酶-24（DHCR24）和前列腺素还原酶 1（PTGR1）基因和蛋白质的表达增加。该提取物还降低了 HO 损伤细胞中的前列腺素 E（PGE）水平，并对重建的人表皮组织细胞（EpiDerm）具有组织修复作用，表明该微藻具有潜在的化妆品活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/c500541d1168/srep41215-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/77f1e58ff4a1/srep41215-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/3c7bed3de11d/srep41215-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/91332ab71bab/srep41215-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/f107f05d38ef/srep41215-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/912de3acb09c/srep41215-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/4614115537cd/srep41215-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/c500541d1168/srep41215-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/77f1e58ff4a1/srep41215-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/3c7bed3de11d/srep41215-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/91332ab71bab/srep41215-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/f107f05d38ef/srep41215-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/912de3acb09c/srep41215-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/4614115537cd/srep41215-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0609/5259714/c500541d1168/srep41215-f7.jpg

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