Ali Tarek Mohamed, El Askary Ahmad
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Saudi Arabia; Department of Medical Physiology, Faculty of Medicine, Beni-Suef University, Egypt.
Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Saudi Arabia; Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt.
Diabetes Metab Syndr. 2018 Nov;12(6):1045-1050. doi: 10.1016/j.dsx.2018.06.022. Epub 2018 Jun 26.
Inconsistent results have been described regarding the part of fetuin-A and testosterone in arterial stiffness in type 2 diabetes mellitus (T2DM).
To look into the links of serum fetuin-A and testosterone levels with brachial-Ankle pulse wave velocity (baPWV), a marker of arteriosclerosis and common carotid intima media thickness (ccIMT), a marker of early atherosclerosis, in diabetic Saudi men patients.
One hundred and fifty adult male patients with T2DM and 60 non-diabetic control subjects were enrolled from different Saudi Arabia Taif hospitals. Biochemical analysis, anthropometric measurements, blood pressure, baPWV and ccIMT were investigated.
Stepwise regression in diabetic patients revealed that the most important predictor of ba-PWV was serum fetuin-A followed by serum glucose and the most important predictor of ccIMT was serum fetuin-A followed by serum HDL then serum triglycerides.
Only fetuin-A levels not testosterone are negatively associated with early markers of atherosclerosis.
关于胎球蛋白-A和睾酮在2型糖尿病（T2DM）动脉僵硬度中的作用，已有不一致的研究结果报道。
探究沙特糖尿病男性患者血清胎球蛋白-A和睾酮水平与肱踝脉搏波速度（baPWV，动脉粥样硬化标志物）及颈总动脉内膜中层厚度（ccIMT，早期动脉粥样硬化标志物）之间的联系。
从沙特塔伊夫不同医院招募了150例成年男性T2DM患者和60例非糖尿病对照者。对其进行生化分析、人体测量、血压、baPWV及ccIMT检测。
糖尿病患者的逐步回归分析显示，ba-PWV的最重要预测因素是血清胎球蛋白-A，其次是血糖；ccIMT的最重要预测因素是血清胎球蛋白-A，其次是血清高密度脂蛋白，然后是血清甘油三酯。
仅胎球蛋白-A水平而非睾酮水平与动脉粥样硬化早期标志物呈负相关。
