丙烯醛对大鼠巨噬细胞功能的影响。

Effects of acrolein on macrophage functions in rats.

作者信息

Sherwood R L, Leach C L, Hatoum N S, Aranyi C

出版信息

Toxicol Lett. 1986 Jul-Aug;32(1-2):41-9. doi: 10.1016/0378-4274(86)90047-0.

Abstract

Male Sprague-Dawley rats were exposed to 0.1, 1.0 or 3.0 ppm acrolein or filtered air 6 h/day, 5 days/week for 3 weeks. Rats were tested one day following the last exposure and exhibited no change in pulmonary clearance of inhaled 35S-labeled Klebsiella pneumoniae at any acrolein concentration. Decreased numbers of peritoneal cells were obtained from exposed rats while the number of cells lavaged from the lungs was unchanged. Macrophages of acrolein-exposed rats had altered phagocytic and enzymatic patterns as compared to macrophages from animals breathing filtered air. However, these changes had no apparent effect on macrophage killing of inhaled bacteria and were therefore probably not indicative of extreme chemical toxicity.

摘要

将雄性斯普拉格-道利大鼠每天暴露于0.1、1.0或3.0 ppm的丙烯醛或过滤空气中6小时，每周5天，持续3周。在最后一次暴露后的一天对大鼠进行测试，结果显示在任何丙烯醛浓度下，吸入的35S标记肺炎克雷伯菌的肺清除率均无变化。暴露大鼠的腹膜细胞数量减少，而从肺中冲洗出的细胞数量未变。与呼吸过滤空气的动物的巨噬细胞相比，暴露于丙烯醛的大鼠的巨噬细胞的吞噬和酶模式发生了改变。然而，这些变化对巨噬细胞杀灭吸入细菌没有明显影响，因此可能并不表明存在极端的化学毒性。