Haesebrouck F, Pensaert M B
Vet Microbiol. 1986 Mar;11(3):239-49. doi: 10.1016/0378-1135(86)90026-x.
Intratracheal inoculation of a field isolate of influenza A H1N1 caused high fever, anorexia and dyspnoea in unvaccinated pigs. In a limited study, it was shown that animals vaccinated once with an inactivated influenza A H1N1 strain showed partial protection at challenge, indicated by mild or absent clinical signs and by the suppression of viral replication. There appeared to be a correlation between the hemagglutination-inhibition titers of the serum of vaccinated pigs and the degree of protection. Animals vaccinated with two spaced injections were completely protected at challenge. Viral replication was inhibited in their respiratory tract since no virus was isolated from animals at slaughter and no increase in antibody titer was observed in challenged vaccinates followed serologically. It was concluded that vaccination of swine against influenza with an inactivated vaccine can result in a protective immunity in the respiratory tract. The New Jersey vaccine strain could protect against swine influenza strains (H1N1) currently prevalent in several European countries.
用甲型H1N1流感病毒野毒株进行气管内接种，可使未接种疫苗的猪出现高热、厌食和呼吸困难。在一项有限的研究中，结果显示，用甲型H1N1流感病毒灭活毒株接种一次的动物在受到攻击时表现出部分保护作用，表现为临床症状轻微或无临床症状，以及病毒复制受到抑制。接种疫苗猪的血清血凝抑制效价与保护程度之间似乎存在相关性。间隔两次注射进行疫苗接种的动物在受到攻击时得到了完全保护。它们的呼吸道中病毒复制受到抑制，因为在屠宰时未从动物体内分离到病毒，且在受到攻击的接种疫苗动物中未观察到血清学抗体效价升高。得出的结论是，用灭活疫苗对猪进行流感疫苗接种可在呼吸道产生保护性免疫。新泽西疫苗株可预防目前在几个欧洲国家流行的猪流感毒株（H1N1）。
