Seo Sang Heui, Webster Robert G
Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.
J Virol. 2002 Feb;76(3):1071-6. doi: 10.1128/jvi.76.3.1071-1076.2002.
Previous studies have associated influenza virus-induced expression of inflammatory cytokines, including tumor necrosis factor alpha (TNF-alpha), with influenza pathogenesis in the human respiratory tract and have suggested that alpha and beta interferons are the first cytokines recruited to counteract such infection. However, we report here that TNF-alpha has powerful anti-influenza virus activity. When infected with influenza virus, cultured porcine lung epithelial cells expressed TNF-alpha in a dose-dependent manner. Expression of TNF-alpha was induced only by replicating virus. TNF-alpha showed strong antiviral activity against avian, swine, and human influenza viruses, and the antiviral effect of TNF-alpha was greater than that of gamma or alpha interferon. These findings suggest that TNF-alpha serves as the first line of defense against influenza virus infection in the natural host.
先前的研究已将包括肿瘤坏死因子α（TNF-α）在内的炎性细胞因子的流感病毒诱导表达与人类呼吸道的流感发病机制联系起来，并表明α和β干扰素是最早被招募来对抗此类感染的细胞因子。然而，我们在此报告TNF-α具有强大的抗流感病毒活性。当感染流感病毒时，培养的猪肺上皮细胞以剂量依赖的方式表达TNF-α。TNF-α的表达仅由复制病毒诱导。TNF-α对禽流感、猪流感和人流感病毒均表现出强大的抗病毒活性，且TNF-α的抗病毒效果大于γ或α干扰素。这些发现表明TNF-α是天然宿主中抵御流感病毒感染的第一道防线。
