Zhang Yangyu, Wu Yanhua, Jia Zhifang, Cao Donghui, Yang Na, Wang Yueqi, Cao Xueyuan, Jiang Jing
Division of Clinical Research, First Hospital of Jilin University, Changchun, Jilin, China.
Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun, Jilin, China.
PeerJ. 2020 Feb 21;8:e8600. doi: 10.7717/peerj.8600. eCollection 2020.
Gastric cancer (GC) remains the third leading cause of cancer death in China. Although genome-wide association studies have identified the association between several single nucleotide polymorphisms (SNPs) on 8q24 and the risk of GC, the role of these SNPs in the prognosis of GC in Chinese populations has not yet been fully evaluated. Therefore, this study was conducted to explore the association between long non-coding RNA (lncRNA) polymorphisms on 8q24 and the prognosis of GC.
We genotyped 726 surgically resected GC patients to explore the association between eight SNPs in the lncRNAs CCAT1 (rs10087719, rs7816475), PCAT1 (rs1026411), PRNCR1 (rs12682421, rs13252298), and CASC8 (rs1562430, rs4871789, rs6983267) transcribed from the 8q24 locus and the prognosis of GC in a Chinese population.
We found that the patients carrying rs12682421 AA genotypes survived for a shorter time than those with the GG/GA genotype (HR = 1.39, 95% confidence interval (CI) [1.09-1.78]). Compared with the CC/CT genotype, the TT genotype of rs1562430 was associated with an increased risk of death (HR = 1.38, 95% CI [1.06-1.80]). Furthermore, the results also identified the rs1026411 SNP as an independent prognostic factor for poor survival in GC patients. Patients carrying AA/AG variant genotypes had a 36% increased risk of death compared to those carrying the GG genotype (HR = 1.36, 95% CI [1.06-1.74]). These findings suggested that the rs12682421, rs1026411 and rs1562430 SNPs may contribute to the survival of GC and be prognostic markers for GC.
胃癌（GC）仍是中国癌症死亡的第三大主要原因。尽管全基因组关联研究已确定8q24上的几个单核苷酸多态性（SNP）与胃癌风险之间的关联，但这些SNP在中国人群胃癌预后中的作用尚未得到充分评估。因此，本研究旨在探讨8q24上长链非编码RNA（lncRNA）多态性与胃癌预后之间的关联。
我们对726例接受手术切除的胃癌患者进行基因分型，以探讨从8q24位点转录的lncRNAs CCAT1（rs10087719、rs7816475）、PCAT1（rs1026411）、PRNCR1（rs12682421、rs13252298）和CASC8（rs1562430、rs4871789、rs6983267）中的8个SNP与中国人群胃癌预后之间的关联。
我们发现，携带rs12682421 AA基因型的患者生存时间短于携带GG/GA基因型的患者（风险比[HR]=1.39，95%置信区间[CI][1.09 - 1.78]）。与CC/CT基因型相比，rs1562430的TT基因型与死亡风险增加相关（HR = 1.38，95% CI [1.06 - 1.80]）。此外，结果还确定rs1026411 SNP是胃癌患者生存不良的独立预后因素。与携带GG基因型的患者相比，携带AA/AG变异基因型的患者死亡风险增加36%（HR = 1.36，95% CI [1.06 - 1.74]）。这些发现表明，rs12682421、rs1026411和rs1562430 SNPs可能影响胃癌患者的生存，是胃癌的预后标志物。
