Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan.
Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan; The Institute of Medical Science, The University of Tokyo, Tokyo 1088639, Japan.
Trends Biochem Sci. 2018 Oct;43(10):818-828. doi: 10.1016/j.tibs.2018.08.006. Epub 2018 Aug 28.
Currently, infertility affects ∼16% of couples worldwide. The causes are reported to involve both male and female factors, including fertilization failure between mature spermatozoa and eggs. However, the molecular mechanisms involved in each step of mammalian fertilization are yet to be fully elucidated. Although some of these steps can be rescued with assisted reproductive technologies, it is important to clarify the molecular mechanisms involved for the treatment and diagnosis of infertile couples. This review illustrates recent findings in mammalian fertilization, discovered by combining gene modification techniques with other new approaches, and aims to show how these findings will guide future research in mammalian fertilization.
目前，全世界约有 16%的夫妇受到不孕不育的影响。据报道，不孕不育的原因涉及男性和女性因素，包括成熟精子和卵子之间的受精失败。然而，哺乳动物受精过程中每一步涉及的分子机制仍未完全阐明。尽管可以通过辅助生殖技术来挽救其中的一些步骤，但阐明涉及的分子机制对于不孕不育夫妇的治疗和诊断很重要。本综述通过结合基因修饰技术和其他新方法，说明了哺乳动物受精过程中的最新发现，并旨在展示这些发现将如何指导哺乳动物受精的未来研究。
